Oxybutynin Hydrochloride in 3 Cases of Clozapine Induced Nocturnal Enuresis / 신경정신의학

Nocturnal enuresis has been recognized as an adverse effect of clozapine treatment. We reported 3 chronic schizophrenic patients who had showed nocturnal enuresis following clozapine treatment. Oxybutynin hydrochloride on clozapine-induced enuresis was very effective in 3 patients. The dose in our patients was 5 to 10mg/day. This medication was well tolerated. It is suggested that oxybutynin hydrochloride is a effective therapeutic option in clozapine-induced nocturnal enuresis.

The Multidimensional Evaluation of Dementia Patients and the Correlation among Measures

OBJECTIVES: Behavioral problem and functional impairment in addition to cognitive impairment are induced, and the medical comorbidity is common in dementia patients. Thus the evaluation of these domains is needed for the management of dementia patients. This study presents a method practically and easily assessing above all dimensions, and analyzes the results. METHODS: The multidimensional evaluating method consists of one general staging measure (GDS) and four measures(MMSE, B-ADL, BEHAVE-AD, GMHR) evaluating four domains;cognition, activities of daily living, behavior, and medical comorbidity. These measures are administered to 29 dementia patients(Alzheimer's dementia 21, mixed or vascular dementia 9) admitted in a long-term care residence of dementia patients. The correlation of measures and the difference of the type of dementia, sex, and age are analysed by Pearson correlation coefficient and independent t-test respectively. RESULTS & CONCLUSIONS: In the correlation of scales, the score of MMSE was significantly correlated to the score of B-ADL in Alzheimer's dementia patient group(p<0.05). The score of B-ADL was significantly higher(p<0.05) and the score of GMHR was statistically insignificantly higher in Alzheimer's dementia patient group than mixed or vascular dementia patient group. The sex and age was unrelated to cognitive or functional ability. This multidimensional evaluating method, including the assessment of the medical comorbidity, is thought to be convenient to apply in the long-term care residence of dementia patients, and be of practical help to the management of dementia patients.