first reported adult case of Lichen planus following rabies vaccination

Lichen planus [LP] is a chronic inflammatory dermatosis. Its etiology remains unknown, but it is regarded as being the result of reactions associated with cell-mediated immunity in the skin. A case of LP resulting from hepatitis B virus vaccination was described, and this was subsequently followed by the reporting of LP cases that were due to human immunodeficiency virus, influenza, and diphtheria-pertussis-tetanus vaccination. Only one pediatric case with LP resulting from the rabies vaccine has been reported. In the present study, the development of LP in an adult male following rabies vaccination was described

Total Serum Oxidant/Antioxidant Status and Arylesterase Activity in Recurrent Aphthous Stomatitis

BACKGROUND: Recurrent aphthous stomatitis (RAS) is a chronic relapsing inflammatory disorder of the oral mucosa with unknown etiology. Oxidative stress (OS) is suggested to play a main role in the etiopathogenesis in RAS. OBJECTIVE: In this study, we hypothesize that a systemic OS is present in patients with RAS. METHODS: Forty-four patients with active RAS lesions and 38 healthy controls were being included in the study. Serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase 1 arylesterase (ARES) activity were being determined. RESULTS: RAS patients had significantly lower TAS levels and higher TOS and OSI values than controls. The patients had a lower ARES activity when compared to healthy controls. No correlations were observed between OS parameters and age, gender, duration of disease or frequency of RAS attacks per month. CONCLUSION: A systemic OS is determined with an imbalance in oxidant/antioxidant status and lower ARES activity in RAS. Systemic OS may have an important role in the pathogenesis of RAS formation.

Total Serum Oxidant/Antioxidant Status and Arylesterase Activity in Recurrent Aphthous Stomatitis

BACKGROUND: Recurrent aphthous stomatitis (RAS) is a chronic relapsing inflammatory disorder of the oral mucosa with unknown etiology. Oxidative stress (OS) is suggested to play a main role in the etiopathogenesis in RAS. OBJECTIVE: In this study, we hypothesize that a systemic OS is present in patients with RAS. METHODS: Forty-four patients with active RAS lesions and 38 healthy controls were being included in the study. Serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase 1 arylesterase (ARES) activity were being determined. RESULTS: RAS patients had significantly lower TAS levels and higher TOS and OSI values than controls. The patients had a lower ARES activity when compared to healthy controls. No correlations were observed between OS parameters and age, gender, duration of disease or frequency of RAS attacks per month. CONCLUSION: A systemic OS is determined with an imbalance in oxidant/antioxidant status and lower ARES activity in RAS. Systemic OS may have an important role in the pathogenesis of RAS formation.