Mode coupling in living systems: implications for biology and medicine.

Complex systems, and in particular biological ones, are characterized by large numbers of oscillations of widely differing frequencies. Various prejudices tend to lead to the assumption that such oscillators should generically be very weakly interacting. This paper reviews the basic ideas of linearity and nonlinearity as seen by a physicist, but with a view to biological systems. In particular, it is argued that large couplings between different oscillators of disparate frequencies are common, being present even in rather simple systems which are well-known in physics, although this issue is often glossed over. This suggests new experiments and investigations, as well as new approaches to therapies and human-environment interactions which, without the concepts described here, may otherwise seem unlikely to be interesting. The style of the paper is conversational with a minimum of mathematics, and no attempt at a complete list of references.

Single photon detectors for biology: present and future.

A summary of the status of present technology for the detection of single photons is presented with a view towards applications in biophotonics. Included are careful discussions of the numerous problems that can be encountered and how to get around them with the hope that this will be of help to biologists interested in doing work in the field of biophotonics. Emphasis is placed on traditional devices, but the field is one which is continuously developing and we review the status of new and very interesting technologies which are becoming available. The paper is meant to be fairly self-contained and assumes no extensive knowledge of the physics of photodetection.