Glomerular diseases outcome at one year in a tertiary care centre

To determine outcome in primary and secondary glomerular diseases at one year follow up. Study design is observational cohort, done in out-patient department, Dow Iinternational Medical College, DUHS. All information gathered on a proforma. All patients with dipstick positive proteinuria and clinical glomerular disease were included in study. Patients with no proteinuria were excluded so were patients with stage 5 CKD. Patients were followed for proteinuria and renal insufficiency at completion of one year follow up. Statistical analysis was done on SPSS version 16. Total number of patients who completed one year follow up was 173. Mean age of patients was 51.67 +/- 10.16 [range 15 to 75 years]. Ninety two [53.2%], were males and 81 [46.8%] were females, ratio being 1.1:1.0. Mean weight of our patients was 67.43 +/- 14.13 Kg, [35 to 107 kg]. Commonest cause of glomerular disease in our patient was diabetic nephropathy which was seen in 94.2% patients. Commonest associated problem with glomerular disease was hypertension seen in 66.5% of patients. Four out of 173 patients had stage 5 CKD at end of follow up at one year while quantitativ proteinuria remained same at one year follow up. One year follow up is critical for patients with glomerular disease associated with stage 4 CKD as progression to end stage renal failure may be seen within one year in these patients

Pyuric diabetic patients: a tertiary centre experience from Karachi

[1] To determine frequency of urinary tract infection among pyuric diabetic patients. [2] To determine sterile pyuria frequency among pyuric diabetic patients. [3] To determine factors predisposing to urinary tract infection. This is a non randomized, prospective observational study done in tertiary care set up of Dow University of Health Sciences, Karachi. Data collection done from June 2013 till August 2013. Sampling was done by convenient method, sample size of 97. Inclusion criteria was all adult [above 16] patients with diabetes mellitus and pyuria [more than 4 pus cells /HPF] whose urine culture report was also available. Verbal consent was sought from patients. All data was collected on a Performa. Data was maintained and analyzed on SPSS version 16. Total number of pyuric diabetic patients in study was 97. Frequency of Urinary tract infection was 59/97 [60.82%], prevalence of culture negative sterile pyuria was found 38/97 [39.17%]. Urinary tract infection was found to be more in females with lower urinary tract symptoms and flank pains. Stone disease, obstructed pelvicalyceal system, proteinuria, high serum creatinine and positive nitrites were found more in culture positive patients than in culture negative pyuric patients. Pyuric diabetic patients in our study population were found to have culture positive UTI in 60.82% and culture negative sterile pyuria among 39.17% of patients. UTI was found more in females, in symptomatic patient and with abnormal urinary tract anatomy and function

Hemodialysis patients profile at Dow university of health sciences, Karachi, Pakistan

To determine the frequency of diseases contributing to End Stage Renal Failure [ESRF] and to determine the frequency of seropositivity for hepatitis B and hepatitis C in our patients. This is an observational study of two years duration from January 2012 till December 2013, done at Dow university of Health Sciences. Sample size is 189 by convenient method. Data collection is retrospective. Inclusion criteria includes all patients ever hemodialysed at DIMC with age 14 or above. Exclusion criteria is age below 14. Data maintained and analyzed on SPSS version 16. All categorical data in percentages and numeric data is given in frequencies and mean with Standard deviation. Total number of patients included in study were 189, Males were 94/189 [49.7%], females were 95/189 [50.3%], Male to female ratio was 0.98:1.0. Mean age was 51.88 +/- 15.2, range was 14-86 years. Patients started on Hemodialysis were found to have hypertension in 40.2%, both diabetes and hypertension was present in 42.8%, diabetes alone in 3.1% of patients as likely etiology of renal failure. Seropositivity for HBV was found 4/189[2.1%] and HCV in 31/189[16.4%] at initiation of Hemodialysis. Hypertension alone is an important disease found in patients with renal failure as likely cause followed by diabetes. Hepatitis C positivity at start of hemodialysis is 16%