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EMHJ-Eastern Mediterranean Health Journal. 2009; 15 (6): 1483-1488
en Inglés | IMEMR | ID: emr-157461

RESUMEN

This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients [102 with venous thrombosis and 26 with arterial thrombosis] attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients [20.3%] than controls [6.0%]. The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified


Asunto(s)
Humanos , Mutación/genética , Trombosis/genética , Prevalencia , Reacción en Cadena de la Polimerasa
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