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Background: Vernal keratoconjunctivitis (VKC) is a recurrent, bilateral, external, ocular inflammation primarily affecting young adults living in warm dry climates. The objectives of the research was to compare the two ophthalmic solutions of olopatadine hydrochloride (0.1%) and epinastine hydrochloride (0.05%) on clinical signs of vernal keratoconjuntivitis and to determine side effects of both the drugs.Methods: The study was carried out in 40 patients who attended the out-patient department (OPD) Ophthalmology, Darbhanga Medical College and Hospital, Laheriasarai from July 2007 to December 2008. Forty patients with symptoms of VKC (ocular itching, ropy discharge, papillary hypertrophy, gelatinous thickening and horner-trantas spots were selected and included in our study.Results: Mean score of palpebral hyperemia at 0, 14, 28 and 42 days in olopatadine treated eye were 2.1, 1.4, 0.8 and 0.4 respectively having p value <0.01, and <0.01 and <0.05 respectively, while mean score at same stages in placebo eye were 2.1, 2, 1.9, and 1.5 having value >0.05. Epinastine treated group mean score of palpebral hyperemia were <0.01 and <0.01 respectively in epinastine treated eye whereas in placebo treated eye, mean score were 2.1, 2.0, 1.8 and 1.6 respectively having p value >0.05 in all stages. Statistically insignificant reduction at day 14 while very significant reduction at day 28 and 42 was observed in epinastine treated eye as compared to placebo.Conclusions: The present study had shown that both olopatadine and epinastine were effective in treating clinical signs of VKC as compared to placebo.
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To determine the frequency of peripheral artery disease [PAD] in diabetic patients by assessing ankle brachial index [ABI]. Cross-sectional study. This study was conducted in the Department of Medicine, Abbasi Shaheed Hospital for a period of six month from September 2011 to March 2012. All type 2 diabetics of more than two years disease duration, on treatment, of either gender, were included between 41 years to 70 years of ages. Peripheral artery disease was assessed by ankle brachial index [ABI]. Frequency and percentages were presented for gender, smoking status, family history of type 2 diabetes and PAD. Mean and standard deviation was presented for age of patients, duration of diabetes and smoking status. Chi square test was used to compare relative frequencies. A total of 125 patients were included with a mean age of 57.10 +/- 8.77 years. 68 [54.4%] were female. Mean duration of diabetes was 4.62 +/- 2.21 years. PAD was found in 74 [59.2%] while 51 [40.8%] patients were free from PAD. A high frequency of PAD was detected in the diabetic subjects with a female pre-ponderance, with statistically significant association with increasing age, hypertension and duration of diabetes
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Fahr's disease refers to a rare syndrome characterized by symmetrical and bilateral intracranial calcification. We describe a 28 year's old unmarried girl who presented with fits, anxiety, and panic attacks. She had bilateral symmetrical intracranial calcification. She was proved to have hypoparathyroidism and pleural tuberculosis
Asunto(s)
Humanos , Femenino , Calcinosis/etiología , Epilepsia/etiologíaAsunto(s)
Humanos , Femenino , Obesidad , Discapacidad Intelectual , Polidactilia , Retinitis Pigmentosa , Hipogonadismo , SíndromeRESUMEN
An open, non-comparative prospective study was carried out on 28 adult patients with confirmed gastro-oesophageal reflux disease [GERD] to evaluate the efficacy of famotidine [40mg b.i.d. for 6 to 12 weeks]. Out of 26 patients [2 lost to follow up], symptomatic relief was observed in 19 [73.08%] patients at 6 weeks and 24 [92.31%] at 12 weeks. Fourteen [53.85%] patients showed endoscopic healing at 6 weeks and 25 [96.15%] at 12 weeks. The results indicate that famotidine is an effective drug in providing symptomatic relief and endoscopic healing in GERD