RESUMEN
We have reported that heat as well as X-rays induced <i>p53</i>-centred signal transduction. The p53 molecule determines the fate of cells, especially apoptosis. Wild-type (wt) <i>p53 </i>cells are resistant to heat as compared with the mutated-type (m) <i>p53 </i>cells. Apoptosis is efficiently induced in the wt<i>p53</i> cells by heat through the activation of Bax and Caspase-3, not but m<i>p53</i> cells. Therefore, we proposed that wt<i>p53</i> patients would be more suitable for hyperthermic therapy than m<i>p53</i> patients. To enhance apoptosis in m<i>p53</i> cells, however, we succeeded the establishing new cancer therapies against m<i>p53</i> cells using chemical chaperon therapy with glycerol and peptide therapy with p53 C-terminal peptide. In addition, we applied siRNA or gene therapy with <i>p53</i>-targeted genes to m<i>p53</i> and <i>p53</i>-deficient cells. It is our hope to show that these new therapies prove more effective as cancer therapies as soon as possible.<br>