RESUMEN
Extramedullary plasmacytoma (EMP) is a rare neoplasm characterized by monoclonal proliferation of plasma cells. They originate in either bone – solitaryosseous plasmacytoma, or in soft tissue – EMP. EMP represents <1% of all head and neck malignancies. The nasal cavity and nasal septum are thecommon sites of occurrence. This is a report of EMP in a 47-year-old gentleman. He presented with a 3-month history of the left nasal blockage andepistaxis. Examination revealed a large reddish to blackish mass of the left nasal cavity. The first biopsy, however, showed benign sinonasal polyps. Biopsywas repeated in view of suspicious clinical and computed tomography features. Histopathology from the second biopsy reported as EMP, confirmed byimmunohistochemical techniques. The patient underwent bone marrow aspirate and trephine, skeletal survey, and laboratory investigations was performedto exclude multiple myeloma. Radiotherapy was initiated.