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China Journal of Chinese Materia Medica ; (24): 2400-2404, 2007.
Artículo en Chino | WPRIM | ID: wpr-307511

RESUMEN

<p><b>OBJECTIVE</b>To investigate the effect of Salvia miltiorrhiza on glomerulosclerosis induced by Ang II.</p><p><b>METHOD</b>Rat mesangial cells were exposed to 100 nmol L(-1) Ang II. Meanwhile, we added S. miltiorrhiza injection of different concentrations to Mcs. PAI-1 mRNA and protein, TGF-beta1 in serum free MEM medium, and the level of cellular reactive oxygen species (ROS) were measured.</p><p><b>RESULT</b>S. miltiorrhiza notably attenuated Ang II induced expression of PAI-1 in a concentration-dependent manner. Meanwhile, S. miltiorrhiza suppressed the production of TGF-beta1 and cellular ROS in mesangial cells.</p><p><b>CONCLUSION</b>S. miltiorrhiza can alleviate glomerular sclerosis. The renoprotective effects of S. miltiorrhiza may be due to its ability to decrease Ang II -induced PAI-1 and TGF-beta1 secretion and cellular ROS level.</p>


Asunto(s)
Animales , Ratas , Angiotensina II , Farmacología , Western Blotting , Células Cultivadas , Relación Dosis-Respuesta a Droga , Medicamentos Herbarios Chinos , Farmacología , Expresión Génica , Inyecciones , Células Mesangiales , Metabolismo , Plantas Medicinales , Química , Inhibidor 1 de Activador Plasminogénico , Genética , ARN Mensajero , Genética , Metabolismo , Especies Reactivas de Oxígeno , Metabolismo , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Salvia miltiorrhiza , Química , Factor de Crecimiento Transformador beta1 , Sangre , Secreciones Corporales
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