comparative study between gliclazide, glibenclamide and glipizide on plasma glucose, C-peptide, lipid profile and on some peroxidative changes in diabetic rats

This study was performed on 50 male adult albino rats [10 normal and 40 alloxan-induced diabetic rats] divided into five groups, each of ten rats. The study recommended the use of gliclazide in NIDDM due to its excellent glycemic control and prevention of the long- term vascular complications; it also restores the abnormalities in lipid peroxides, oxidative markers and antioxidant enzymes