effect of essential hypertension on serum uric acid level

Patient with arterial hypertension and no definable cause are said to have essential, primary or idiopathic hypertension. A total of 100 patients suffering from essential hypertension and 100 control subjects with almost same mean age and sex distribution were enrolled in this study. Levels of serum uric acid, total cholesterol, TG, and HDL-c were determined by enzymatic colorimetric method. Serum LDL-c and VLDL-c was calculated by using Friedewald and Wilson's formulae. The study was aimed to find out the levels of serum uric acid and lipid profile in patients with essential hypertension and to compare them with levels of normal healthy individuals. Results show increased level of serum uric acid and lipid parameters except for HDL-c, which was significantly, decreased in patients with essential hypertension as compared to the control subjects. Variations in aforementioned parameters were also observed on comparing the obese and the non-obese patients. It can be concluded from the present study that the essential hypertension is associated with abnormalities in the levels of serum uric acid and lipid profile

Glycated hemoglobin [HBA1, HBA1C], a reliable parameter for evaluation of diabetic control

There are several methods for assessing diabetic control. Urine glucose estimation may be misleading and the numerous blood glucose estimation per day may be very cumbersome. Glycated hemoglobin on the other hand is a very reliable indicator to assess the level of diabetic control over the preceding two months interval and in contrast to blood glucose estimations it is not affected by moment to moment rise and fall in blood glucose levels. A significant reduction in diabetic complications is noted if glycated hemoglobin is kept around 7.2% by strict control of blood glucose levels

economical and reliable colorimetric method [Thiobarbituric acid oxalic acid] for estimattion of glycosylated hemoglobin [HBA1c]

To set up a reliable, standard and economical colorimetric method for routine HbA1c measurements in diabetics. Design: Three hundred tests were carried out on diabetics by colorimetric method. Interobserver error of the method and reliability were checked and standardization was done in comparison with the chromatographic method. Settings: Metabolic Research Laboratory, East Medical Ward, Mayo Hospital Lahore. Interobserver reliability and error of the method was acceptable. The colorimetric method was standardised comparing it with the chromatographic method. Colorimetric method is reliable and economical for routine use