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1.
Journal of the Arab Board of Medical Specializations. 2008; 9 (1): 64-69
en Inglés | IMEMR | ID: emr-88344

RESUMEN

To explore cellular immunity against Toxoplasma gondii in Iraqi women with a history of abortion using the immunostaining method. Sixty women who had abortion were selected for this study. The presence of anti-Toxoplasma antibodies in their sera was confirmed via ELISA testing. Heparinized blood and serum were collected. The women were divided into three groups according to the presence of specific anti-Toxoplasma antibodies in their serum. These groups included: women with IgG [18], women with IgM [14] and women with both IgG and IgM [12]. The other 16 women had no antibodies against Toxoplasma. Twenty-four healthy-looking women had been selected as controls. Those that revealed any antibody titer against Toxoplasma were excluded from the study. The isolated peripheral blood leukocytes [PBL] were tested for cell surface markers [CD3, CD4, CD8 and CD71] using monoclonal antibodies against T-cell subsets. All the surface makers revealed significantly higher percentages when compared to the healthy controls. The results indicate a strong cellular immune response during toxoplasmosis


Asunto(s)
Humanos , Femenino , Inmunidad Celular , Aborto Espontáneo/parasitología , Ensayo de Inmunoadsorción Enzimática , Anticuerpos Antiprotozoarios , Inmunoglobulina G , Inmunoglobulina M , Complejo CD3 , Antígenos CD4 , Antígenos CD8 , Subgrupos de Linfocitos T , Anticuerpos Monoclonales , Antígenos CD
2.
LMJ-Lebanese Medical Journal. 2006; 54 (4): 196-199
en Inglés | IMEMR | ID: emr-78908

RESUMEN

Transitional cell carcinoma [TCC] of the bladder remains a significant health problem worldwide. The molecular mechanisms of tumor development and progression are complicated but likely involve the interaction of tumor suppressor genes, oncogenes, cell cycle regulatory proteins and other factors. Hence, this study attempts to explore the role of nuclear factor-kB [NF-KB] in the TCC of the bladder in correlation with different clinicopathological criteria which are tumor grade, muscle invasion by the tumor, schistosomiasis and presentation whether primary or recurrent tumor. Twenty patients with TCC of the bladder were included in the study from June 2003 to June 2004, and were diagnosed by histopathology. The expressions of the transcription factor NF-kB were studied by in situ hybridization technique [ISH]. The results showed that there was a significant correlation [p<0.05] with muscle invasion and schistosomiasis but not with other criteria. The current study showed the possible role of the transcription factor [NF-kB] in TCC of the bladder


Asunto(s)
Humanos , Masculino , Femenino , Carcinoma de Células Transicionales/etiología , FN-kappa B/efectos adversos , Hibridación in Situ , Esquistosomiasis
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