RESUMEN
Our experimental study showed that in a dose related manner SP has successful inhibitory effect on the rat uterine horn, and also on the smooth muscle organs; ileum and trachea. We guess that SP can be used in well regulated dosed with least side effects to arrest preterm labor on human being in the future. Up to date there is no manuscript about contraction inhibitory effect of SP on the uterus. We hope this study will be of scientific help.
Asunto(s)
Animales , Dietilestilbestrol/farmacología , Relación Dosis-Respuesta a Droga , Femenino , Íleon/efectos de los fármacos , Isoxsuprina/administración & dosificación , Contracción Muscular/efectos de los fármacos , Ratas , Ratas Endogámicas , Ritodrina/administración & dosificación , Espironolactona/administración & dosificación , Tráquea/efectos de los fármacos , Contracción Uterina/efectos de los fármacosRESUMEN
The spontaneous contractions of the rabbit uterine horns and the human myometrial strips were stimulated by oxytocin and buserelin acetate in isolated preparations. Spironolactone application to these models produced inhibitory effects on the contractions. It is concluded that spironolactone has inhibitory effect on the rabbit uterine horn and the human myometrial strip contractions.