RESUMEN
Dendroaspis angusticeps venom (75 micrograms/ml) caused an irreversible blockade of the directly as well as directly evoked contractions of the rat hemidiaphragm and indirectly evoked contractions of the chick biventer cervicis muscle. The venom itself also produced a contraction of the frog rectus abdominis muscle, rat fundal strip, rat uterus and nictitating membrane of the cat; however, it did alter responses of nictitating membrane to preganglionic electrical stimulation and to ganglion stimulant drugs. The effect was attributed to the presence of acetylcholine-like substance in the venom.
Asunto(s)
Animales , Gatos , Pollos , Venenos Elapídicos/farmacología , Estimulación Eléctrica , Femenino , Yeyuno/fisiología , Contracción Muscular/efectos de los fármacos , Conejos , Ranidae , Ratas , Ratas Endogámicas , Contracción Uterina/efectos de los fármacosRESUMEN
Whole venom Dendroaspis angusticeps produced a negative chronotropic and ionotropic effect on the heart. Isolation of the fraction (T39) produced the same effect. Negative inotropic effect was blocked by atropine. The bradycardia may be due to a cholinergic effect and the negative ionotropic to a direct depressant effect on the myocardium.