RESUMEN
Cancrum oris (noma) has been most commonly described in malnourished debilitated children with poor oral hygiene following systemic childhood infections such as measles, pertussis or scarlet fever. We describe a patient who developed this condition during a period of profound neutropenia following cytotoxic chemotherapy for acute lymphoblastic leukaemia.
Asunto(s)
Humanos , Femenino , Adulto , Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamiento farmacológico , Neutropenia/inducido químicamente , Noma/inducido químicamente , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Gangrena , Inducción de Remisión , Infecciones Estafilocócicas/inducido químicamente , Infecciones Estafilocócicas/patología , Infecciones por Klebsiella/inducido químicamente , Infecciones por Klebsiella/patología , Infecciones por Pseudomonas/inducido químicamente , Infecciones por Pseudomonas/patología , Klebsiella pneumoniae , Leucemia-Linfoma Linfoblástico de Células T Precursoras/patología , Labio/patología , Mucosa Bucal/patología , Neutropenia/patología , Noma/patología , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Pseudomonas aeruginosaRESUMEN
We report an unusual case of modular sclerosing Hodgkin's disease in a 17 year old women presenting with intermittent fever, progressive weight loss and enlarged cervical and anxillary lymp nodes. Laboratory test revealed severe Coombs' positive haemolytic anaemia, and progressive thrombocytopenia and leucopenia, associated with erythroid, myeloid and megakaryocytic hyperplasia, but with no evidence of lymphomatous infiltration in the bone marrow. Transfusion of compatible blood became possible only after prednisone therapy and a single intravenous dose of vincristine. Appropriate chemotherapy led to normalization of the peripheral blood counts and a negative direct Coombs' test.