Mis-sizing of Adenomatous Polyps is Common among Endoscopists and Impacts Colorectal Cancer Screening Recommendations

BACKGROUND/AIMS: To determine the accuracy of identifying ≥6-mm adenomatous polyps during colonoscopy and define its impact on subsequent interval screening. METHODS: We conducted a retrospective study of patients who underwent colonoscopies at Banner University Medical Center, Tucson from 2011 to 2015. All patients with ≥6-mm adenomatous polyps based on their colonoscopy report were included. Adenomatous polyps were excluded if they did not meet the criteria. Discrepancies in the polyp size were determined by calculating the percentage of size variation (SV). Clinical mis-sizing was defined as SV >33%. RESULTS: The polyps analyzed were predominantly <10 mm in size. Approximately 13% of the examined polyps met the inclusion criteria, and 40.7% of the adenomas were ≥10 mm. A total of 189 ≥6-mm adenomatous polyps were collected from 10 different gastroenterologists and a colorectal surgeon. Adenomatous polyps were clinically mis-sized in 56.6% of cases and overestimated in 71.4%. Among the adenomas reviewed, 22% of mis-sized polyps and 11% of non-mis-sized polyps resulted in an inappropriate surveillance interval. CONCLUSIONS: We found that more than half of ≥6-mm adenomatous polyps are mis-sized and that there is a tendency to overestimate adenoma size among endoscopists. This frequently leads to inappropriate intervals of surveillance colonoscopy.

Exposure to Extremely Low Frequency Magnetic Fields Induces Fos-Related Antigen-Immunoreactivity Via Activation of Dopaminergic D1 Receptor

We previously demonstrated that repeated exposure to extremely low frequency magnetic fields (ELF-MF) increases locomotor activity via stimulation of dopaminergic D1 receptor (J. Pharmacol. Sci., 2007;105:367-371). Since it has been demonstrated that activator protein-1 (AP-1) transcription factors, especially 35-kDa fos-related antigen (FRA), play a key role in the neuronal and behavioral adaptation in response to various stimuli, we examined whether repeated ELF-MF exposure induces FRA-immunoreactivity (FRA-IR) in the striatum and nucleus accumbens (striatal complex) of the mice. Repeated exposure to ELF-MF (0.3 or 2.4 mT, 1 h/day, for consecutive fourteen days) significantly induced hyperlocomotor activity and FRA-IR in the striatal complex in a field intensity-dependent manner. ELF-MF-induced FRA-IR lasted for at least 1 year, while locomotor activity returned near control level 3 months after the final exposure to ELF-MF. Pretreatment with SCH23390, a dopaminergic D1 receptor antagonist, but not with sulpiride, a dopaminergic D2 receptor antagonist, significantly attenuated hyperlocomotor activity and FRA-IR induced by ELF-MF. Our results suggest that repeated exposure to ELF-MF leads to prolonged locomotor stimulation and long-term expression of FRA in the striatal complex of the mice via stimulation of dopaminergic D1 receptor.

Rapid detection of fungal keratitis by semi-nested PCR

Background: Fungal keratitis is a serious ocular infection that can cause corneal scarring and blindness. Currently, diagnosis of fungal pathogens remains a difficult problem. Objectives: To investigate the application of semi-nested PCR targeted ITS genes for detection of fungal agents causing keratitis. Material and method: Ten identified fungal strains, 4 bacterial strains, 20 scraping samples from patients with suspected fungal keratitis and 2 scraping samples from patients with suspected bacterial keratitis were tested using semi-nested PCR. Results: Semi-nested PCR showed positive results for the samples of identified fungal strains and for the 20 scraping samples from patients with suspected fungal keratitis. Neither samples of bacterial strains nor scraping samples from suspected bacterial keratitis patients gave positive PCR results. Conclusion: Semi-nested PCR is a robust tool for specific and rapid detection of fungal agents causing keratitis.

Clinical characteristics and molecular characteristics of\r\n', u'hepatitis B virus in chronic hepatitis B virus infected patients\r\n', u'with A1899 mutation in precore region\r\n', u'

Background: Hepatitis B is an infectious illness caused by hepatitis B virus (HBV) which infects the liver of hominoidea, including humans, and causes an inflammation called hepatitis. Objectives: The aim of study is to clarify clinical features and molecular characteristics of HBV in chronic HBV-infected patients with A 1899 mutation. Subjects and method: HBV genotype, HBV-ONA level, HBeAg and anti-HBe in 29 chronic HBV-infected patients were determined by PCR-RFLP, Real-time PCR and ELISA, respectively. Mutations were analyzed by direct sequencing. Results: Mutations in core-promoter/precore regions of HBV genome can suppress HBeAg secretion and stimulate HBV-ONA replication. The prevalence of hepatocel- lular carcinoma (HCc): 10/29, liver cirrhosis (LC) : 15/29 are significantly higher than that in chronic hepatitis (CH) : 4/29 (P < 0.001). HbeAg seroconversion rate in CH (75%) is higher than that in HCC \r\n', u'(40%) and in LC (53.3%), but not significant (P > 0.05). ALT level is the highest in CH and the lowest in HCC \r\n', u'(P = 0.02), 8/10 (80%) HCC patients have normal range of ALT. HBV-ONA level in HCC and in LC is significantly higher than that in CH (P = 0.024). The emerging of A 1899 is often accompanied by C/G1753 mutation (37.9%) and dual core-promoter mutation T1762A1764 (79.3%). Conclusion: A1899 mutation can play a role in the pathogenesis of liver diseases in chronic HBV-infected Vietnamese.\r\n', u'

Evaluating clinical experience from a case of hepatocellular carcinoma with combinated therapy of transarterial chemoembolization and percutaneousethanol injection afterward emerging metatasis caused by fine needle aspiration cytology

Background: Hepatocellular carcinoma (HCC) is the most common primary hepatic tumor and one of the most common cancers worldwide. HCC is a primary malignancy of hepatocellular origin. Objectives:The aim of study is to combinate therapy of transarterial chemoembolization and percutaneousethanol injection afterward emerging metatasis caused by fine needle aspiration cytology. Subjects and method: A 50 years old male patient with hepatocellular carcinoma having a diameter of tumor more than 5 cm was treated by combination of transarterial chemoembolization and percutaneous ethanol injection from December 2000. Results & Conclusion: Results of study showed that: Transarterial chemoembolization and percutaneous ethanol injection are the two of non-surgical methods for treatment of hepatocellular carcinoma which are most commonly available in applied clinical activities at present. Up to now, the patient's life expectancy after therapy is more than 6 years that means the result of treatment is very good. However, the emerging metatasis into the anterior-right-Iower chest wall that was caused by fine needle aspiration cytology should be reviewed for further evaluating clinical experience, especially in cases with quite clear imaging features of untrasonography and significantly elevated AFP level higher than 200 ng/rnl.

Studying the therapeutic effects of the traditional remedy of "tu than hoan" in the treatment of irritable bowel syndrome of diarrhea state

Background: Irritable bowel syndrome is a diagnosis of exclusion. It is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause."Tu than hoan" is a traditional remedy applied for the treatment of syndromes of traditional medicine which have the similar characteristics to irritable bowel syndrome of diarrhea state of modern medicine. Objectives: The study had two purposes: (1)To evaluate the therapeutic effects of the remedy on the clinical symptoms of patients with irritable bowel syndrome of diarrhea state comparing with Duspatalin; (2)To evaluate the side effects of the remedy. Subjects and method:162 patients diagnosed with irritable bowel syndrome of diarrhea state were treated at Bach Mai hospital from March to August 2005. They divided into 2 groups, the control group included 77 patients and the study group included 85 patients. : clinical test, comparing with controls. Results: 80% of patients recovered from diarrhea; 82.4% of patients with defecation returned to normal; 93.6% stopped mucous feces; 76.5% stopped bellyache. Good therapeutic effect was 61.2% (p < 0.05). Conclusions: Tu than hoan had good therapeutic effects in the treatment of irritable bowel syndrome of diarrhea state. None of patients had to discontinue the medicine due to side effects. \r\n', u' \r\n', u'

Acute respiratory infection and the efficacy of bronchovaxom for preventive treatment

Background:Respiratory infection is a disease which the incidence and mortality rank highest among children diseases under 5 years old. The reasons caused respiratory infection are virus, bacterium and parasite. H.Influenzae, St.pneumoniae and M.Cataralis are the main reason leading to respiratory infection. Objectives:This study aims to research on the efficacy of Bronchovaxom in reducing the rate of acute respiratory infection in children. Subjects and method:A descriptive, prospective and cohort study was conducted on 60 patients was used Bronchovaxom for two times with the 6 months of interval in the National Hospital for Pediatric from January 2006 to September 2007. Results:Among the first selection 60 children, 15 children stopped to participate in the study. The age ranged from 32 months to 88 months, the mean age was 55.4 months. Male was 30 (66.7%); female was 15 ( 33.3%). 100% were injected vaccination. There was a clear reduction in the incidence. The frequency of antibiotic use was also reduced. In particular, increased level of IgA in the patient's saliva following treatment with Bronchovaxom. Conclusion:There was a significantly statistical difference on the times of acute recurrentrespiratory infection in one year on the same patient before and after using Bronchovaxom.

MB2 canal detection using dental loupe and ultrasonic tip

Background: In Vietnam, using dental loupe and ultrasonic tip to detect MB2 canal in mesiobuccal roots of maxillary molars is appropriate and necessary. Objective: The purpose of this study is to assess the effectiveness of magnification and dentine removal when locating the second mesiobuccal canal (MB2) in mesiobuccal roots of maxillary molars. Subject and methods: 49 mesiobuccal roots of maxillary molars were collected and studied. Conventional access of the cavity was prepared. After that, the MB1 and 2 canals in mesiobuccal roots were located in three stages. Stage 1: canals were located with no magnification. Stage 2: additional canals in the same teeth were located under magnification with a dental loupe. Stage 3: additional canals in the same teeth were located by removing dentine from the pulp chamber floor within 3mm from the MB1 canal towards the palatal canal in a groove 2 mm deep using ultrasonic tip (P5, Salatec). Result: The frequency of MB2 canal detection for an ultrasonic tip, dental loupes, and no magnification groups was 77.6%, 59.2% and 24.5%, respectively. Conclusion: Based on these results, more emphasis should be placed on the importance of using magnification dental ultrasonic tip to locate the MB2 canal.

Effects of calcium supplemented biscuits on bone density

2 group of 45 women each, 60-70 years of age, were recruited for this study during 6 months. All women did morning physical exercise regularly. The first group received a daily suplementation of 50g biscuits cotaining 400mg calcium gluconate and the second group received the same amount of biscuits without calcium addition. The bone mineral density was measured at baseline and after 6 months. The results: in the calcium group, there was a significant increase of bone mineral density compared to the control group. The mean systolic and mean diastolic blood pressures found decreased in the calcium group and increased in the control group.

Application of the radio immunological technique for monitoring the changes of markers of hepatitis B HBV in the chronic HBs Ag carrying persons without the clinical menifestation

A study aimed at application of the radio-immunological technique to monitor the changes of markers of HBV in the natural progress of the chronic HBsAg from which to find persons having the risk of severe complication. 50 patients carrying the chronic HBsAg without the clinical menifestation were tested four times every 10 months to evaluate the changes of markers of HBV. The results have shown that the patients had the antibody immunological response during the chronic HBsAg carrage.. The anti-HBc IgG was possitive in 100% patients through 4 times of tests.

Application of software program in the ecological analysis of medicinal plants of Dao ethnic minority at BaVi commune

DECODA is a ecological model. Functions of DECODA include: research, analysis and management of population and community. Master file of DECODA contains species variables, community data and sample variables. DECODA includes 3 modules: MDS, DECORANA, TWINSPAN. Applying DECODA in analyzing medicinal plant (MP) gardens of Yao ethnicity in TWINSPAN classifies 56 MP gardens into 6 groups based on characteristics of MP: I, II, III, IV groups include MPs that fit with high sunlight, heavy soil, medium moisture and poor humus soil. V, VI groups are in opposition to the above groups. DECORANA classifies the MP gardens into 7 groups based on characteristics of gardens: I, II, III, IV groups have a favourable conditions for growing MP and the owner of the gardens pay more attention in growing MP. V, VI groups are in opposition to the above groups.

Role of calcium supplemented cakes in the improvement of bone density

A public nutritional intervention trial on 45 women (ages of 60-70) by using the calcium complemented cakes and 45 women by using common cakes in Namdong and Giang vo communes, Hanoi capital aimed at evaluating the bone density and cardiovascular indices after intervention. The results have shown that the use of calcium supplemented cakes increased the T score of 0,1g/cm2 in the arm and T score of 0,17g/cm2 in the leg of menopausal women and reduced the systolic and diastolic pressure 2,9mmHg and 3,9 mmHg, respectively.