The research progress of novel anxiolytics / 中国药理学通报

Anxiety disorder holds the highest prevalence among adults in China, whereas the research and development of its therapeutic drugs are relatively backward. At present, the commonly used anxiolytics in clinical practice are some benzodiazepines, non-benzodiazepines, and antidepressants, most of which have unpleasant side effects. By searching the literature in Pubmed, we here summarized the research progress of novel anxiolytics in recent years from the following aspects: endocannabinoid system, gut-microbe-brain axis, and GABA