Pharmacokinetics of the alkaloids from the processed seeds of Strychnos nux-vomica in rats / 药学学报

<p><b>AIM</b>To study the pharmacokinetic process about the concentration in rat plasma of the alkaloids from processed seeds of Strychnos nux-vomica with RP-HPLC method.</p><p><b>METHODS</b>Hypersil BDS C18 column was used and the mobile phase consisted of acetonitrile-water at the flow rate of 0.8 mL.min-1. The UV detection wave length was 254 nm.</p><p><b>RESULTS</b>The concentration-time data of strychnine, brucine, strychnine N-oxide and brucine N-oxide were all in accordance with an open two-compartment model after i.v. alkaloids. Their parameters were as follows: T1/2 alpha were (8 +/- 5), (4 +/- 3), (6.2 +/- 1.7) and (3.0 +/- 0.8) min, T1/2 beta were (262 +/- 125), (416 +/- 131), (285 +/- 50) and (342 +/- 141) min, CL were (17 +/- 4), (21 +/- 12), (1.9 +/- 1.8) and (2.8 +/- 1.1) mL.min-1, Vc were (1.4 +/- 0.5), (1.7 +/- 1.1), (0.24 +/- 0.16) and (0.23 +/- 0.06) L.kg-1, Vd were (6.0 +/- 1.2), (12 +/- 7), (0.8 +/- 0.6) and (1.5 +/- 0.6) L.kg-1, AUC were (57,578 +/- 25,578), (35,240 +/- 15,616), (93,088 +/- 22,375) and (177,712 +/- 120,110) h.microgram.L-1, respectively.</p><p><b>CONCLUSION</b>The method is a good reference for pharmacokinetics in human bodies.</p>

Study on process of removing impurity from water-extraction of gutianquan-capsule / 中国中药杂志

<p><b>OBJECTIVE</b>To study the result of removing impurity from water-extraction of Gutianquan-capsule with macro-reticular absorbing resin, chitosans clarification, water-extraction and alcohol-precipitation methods.</p><p><b>METHOD</b>Coefficient of Unguent of macro-reticular absorbing resin, chitosans clarification method, water-extraction and alcohol-precipitation methods were compared, and qualitative assay of Ginsenoside Rg1, Re, and snide measurement of Ginsenoside Rg1, Ferulic acid, and stability experiment were made.</p><p><b>RESULT</b>Coefficient of Unguent of water-extraction and alcohol-precipitation method was 17.2%, Coefficient of Unguent of chitosans clarification method was 12.8%, and macro-reticular absorbing resin method was 3.1%. They could clarify liquor of water-extraction.</p><p><b>CONCLUSION</b>Chitosans clarification method is suitable for process of Gutianquan-capsule.</p>