Clinical study on treatment of HIV infected persons based on viral load detection and CD4+ T lymphocyte counting / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To study the usage of viral load and CD4+ cell count methods in evaluating the effects of clinical treatment in HIV infected people.</p><p><b>METHODS</b>Totally 73 cases of HIV infected persons were studied with clinical observation and laboratory examinations, six cases were treated with cocktail therapy, 36 cases with chinese herbs and the other 31 cases were untreated.</p><p><b>RESULTS</b>The results indicated that the viral load levels in cocktail therapy group were significantly lower than the other two groups within 3 months and then kept at very low level. The CD4+ T lymphocyte levels showed a significant increase after 3 months and kept rising up. The chinese herb group, however, had no significant difference in viral load level and CD4+ T lymphocyte level as compared with untreated group. But in clinical observation chinese herbs showed the effect of improving clinical status in some cases.</p><p><b>CONCLUSIONS</b>The authors conclude that the viral load and CD4+ count are efficient methods in clinical evaluation of HIV treatment, especially in routine anti-HIV therapy. As for the chinese herbs treatment, these two monitors did not reflect changes in clinical status.</p>

Serologic evidence of quality improvement of domestic HIV-antibody detecting ELISA kits / 中国输血杂志

Objective To investigate the quality of current domestic HIV antibody detecting kits and to assure the credibility of experimental results.Methods The sensitivity and specificity of three kinds of domestic HIV antibody detection ELISA kits made in three different years were evaluated and compared by testing the serum panel from National AIDS Reference Laboratory.Results The sensitivity of kits produced by three domestic manufacturers in 2001 is significantly better than the kits produced in 1998 and 1999.The false negative rates were apparently decreasing.Conclusions The quality of domestic HIV antibody detecting kits has been improving steadily.The sensitivity of double antigen sandwich ELISA assay is apparently better than the indirect ELISA assay.