Abordagem psico-social do paciente epiléptico: análise de 30 pacientes adultos / Psychosocial approach of epileptic: analysis of 30 adult cases

Para o estudo de aspectos psico-sociais da vida de pacientes com epilepsia selecionamos, para entrevistas, grupo de 30 epilépticos atendidos ambulatorialmente. Optamos por estudar pacientes adultos com idades superiores a 18 anos, pois, a partir dessa idade se espera que o indivíduo esteja apto para se engajar, por si mesmo, em atividade de natureza profissional, familiar, social, acadêmica, afetiva, sexual e religiosa. Ficou claro, na amostra analisada, que pacientes epilépticos carregam consigo limitaçöes penosas em seus ajustamentos psico-sociais

Preferred structures of constrained peptides from achiral α,α-dialkyiated glycyl residues with acyclic side chains.

Conformational energy computations of the monopeptides from three achiral α,α− dialkylated glycyl residues with acyclic side chains (namely α,α-dimethyl-; α,α−diethyl-; and a, adi- n-propylglycines) are reported as a function of the relevant N-Cα-C' bond angle. In parallel, experimental studies were performed in the solid state (infrared absorption and X-ray diffraction) and in solution (infrared absorption and proton magnetic resonance) on the corresponding protected homo-peptide series (the former series to the dodecamer, the other two series to the pentamers). The results obtained unequivocally indicate that the preference from a helical to a fully extended conformation increases as side-chain bulkiness increases. The longest homo-peptides from α,α−dimethylglycine form stable 310-helices. A picture of the mode of self-association of the helical structures has also been determined. The results of the theoretical analyses fit well with the experimentally observed conformational properties in the solid state and in chloroform solution.