RESUMEN
Sarcoidosis is a multisystem disease of obscure etiology that may involve almost any organ system; therefore, it results in various clinical manifestations. We are presenting a case of 60-year-old female complaining of multiple raised skin colored, to reddish lesions over face and few lesions over neck and extremities since 4 months cutaneous examination revealed multiple well defined skin colored to erythematous papulo-nodular lesions involving whole face with few discrete papular lesions over neck and extremities. Nasal skin was globular, studded with multiple nodules suggestive of lupus pernio. Histopathology showed many non-caseating naked epithelioid cell granulomas of variable sizes in the dermis. He was given oral methylprednisolone 16 mg twice daily after meal along with oral methotrexate 15 mg once in a week and tablet hydroxychloroquine 200 mg twice daily with keeping an eye over related adverse effects of all prescribed drugs. Still patient did not get remission after 6 months of a complete therapy. Due to the rarity of this disorder and its non-responding nature and course with conventional modalities of treatment made us to report this article for further studies and research.