RESUMEN
In silkworm, prothoracicotropic hormone (PTTH), directly or indirectly controls silk production and spinning activity along with juvenile hormone (JH). An effort was made to exploit the potential of PTTH by indirectly activating silk gland for increasing silk productivity using short chain synthetic analogues of PTTH. The analogy in action was also established using PTTH extracted from the silkmoth. Different doses of 42 synthetic PTTH analogues, viz., 2.5, 5, 10 and 20ppm and 3.3 mg/ml of PTTH extracted from silkmoth heads were administered orally to V instar silkworm larvae (Race:KAxNB4D2 and PMxNB4D2) at 0-144 hr at an interval of 24 hr. The analysed data showed an improvement of about 14 - 23% in KA x NB4D2 and about 10-14% in PMxNB4D2 in respect of cocoon shell weight on administration of some of the synthetic PTTH analogues. The PTTH extracted from the adult brain also showed similar effect. The structural analogy of synthetic PTTHs (which improved the shell weight) with original PTTH and its probable mode of action in silkworm are discussed.