An Adolescent Female Presenting with Classical Clinical and Immunological Features of Isoniazid Induced Lupus

Drug induced Lupus Erythematosus (DILE) is a form of rare adverse drug reaction caused due to many drugs, including Isoniazid. Diagnosis is made on the basis of a temporal relationship between the drug administered and the onset of symptoms and on the basis of the antibody profile. We describe the case of a 13 year old female who was diagnosed as having abdominal tuberculosis and was put on ATT and later presented with signs and symptoms of Lupus Erythematosus, with a history of photosensitivity, oral ulcers, and malar rash. Keywords: Isoniazid, Tuberculosis, Drug Induced Lupus

Epidemiological Study of Host Factors Responsible for Tinea Cruris Infection & Clinical Resistance to Treatment

Background: Superficial fungal infection are most common fungal infection affecting 20 -25% of population living in tropical and subtropical countries. Global warming, rapid industrialization, migration of population and changing lifestyle are contributory factors. Aim: To study the host factors responsible for Tinea cruris infection and clinical resistance to treatment. Methods: Hundred patients of tinea cruris were taken for study and data regarding age, occupation, income, education and prior treatment taken was collected. Modified Kupuswamy scale 2017 was applied for socioeconomic status. Results: ‘Majority of patients were males (85%). Young adults (20-40 years) with low socioeconomic status were predominantly affected. Application of steroids and poor compliance to treatment were contributory factors in development of clinical resistance to treatment. Conclusion: By improving working environment and socioeconomic status, mass awareness, proper counseling we can restrain the ongoing epidemic of dermatophytes infection.