RESUMEN
The histamine-induced contraction on chicken oesophagus was antagonised non-competitively by atropine, hexamethonium, cocaine, methysergide, indomethacin, theophylline and verapamil. Physostigmine slightly potentiated the excitatory action of histamine. These results indicate that histamine excreted its excitatory action by involving a number of mechanisms as suggested in guinea pig oesophagus.
Asunto(s)
Animales , Atropina/farmacología , Pollos , Esófago/efectos de los fármacos , Femenino , Histamina/farmacología , Masculino , Contracción Muscular/efectos de los fármacos , Fisostigmina/farmacología , Teofilina/farmacologíaAsunto(s)
Animales , DDT/farmacología , Malatión/farmacología , Masculino , Ratones , Sueño/efectos de los fármacos , Tiopental/farmacologíaRESUMEN
5-Hydroxytryptamine and histamine were estimated in lungs, liver, spleen and adrenals of chicken. A substantial amount of both the amines was found in all the organs. The highest level of both the amines was found in adrenals followed by spleen, lungs and liver. The level of 5-hydroxytryptamine was, however, higher than histamine in all the tissues except adrenals.