RESUMEN
Aims: This study investigated the effect of ethanolic seed extract of Citrullus lanatus (ESECL) on blood glucose level and lipid profile in Alloxan-induced diabetic male Wistar rats. Study Design and Methodology: 30 male adult wistar rats were grouped randomly into six experimental groups of five rats each. Diabetes was induced by intraperitoneal injection of 100 mg/kg of alloxan monohydrate, dissolved in normal saline, while the normal control group (group 1) was given the vehicle only. Three days after induction of diabetes, were treated further for four weeks with ESECL at doses of 100, 200 and 400 mg/kg for groups 4, 5, and 6 respectively. Animals in Group 3 were treated with Glibenclamide (2.5 mg/kg), while group 2 served as the negative control group. Results: Administration of ESECL caused significant decrease in blood glucose levels in groups 4, 5 and 6 compared to rats of group 2 (p=0.00125). There was also significant decrease in the levels of cholesterol (TC) , triglycerides (TG), low density lipoprotein (LDL), with increase in high density lipoprotein (HDL) in Groups 4, 5 and 6, compared to Group 2 rats (p=0.00125). The results obtained from the rats of the group receiving extract were similar to that obtained from Groups 3. Conclusion: Thus, this study suggests that this extract could possibly normalize abnormalities in blood glucose levels and lipid profiles in diabetic conditions in a dose dependent manner.
RESUMEN
The effects of Xanthosoma sagittifolium [tannia] and Colocasia esculenta [taro] based diets on hepatic cholesterol and phospholipid levels in albino rats were studied. Fifty albino rats randomly distributed into 5 groups [I-V] of 10 rats each, were respectively fed growers mash as the control diet and 25% tannia, 50% tannia, 25% taro and 50% taro supplemented diets respectively for a period of 30 days. Hepatic cholesterol and phospholipid concentrations were measured spectrophotometrically. There were statistically significant decreases in hepatic total and esterified cholesterol concentration in rats fed with the taro and 50% tannia supplemented diets when compared with those on control diet [P< 0.05]. However, only rats fed with 50% tannia supplemented diet showed significant decrease in hepatic free cholesterol compared with controls [P< 0.05]. Rats fed with tannia supplement showed non-significant elevation in hepatic phospholipid concentration, while those fed with taro supplement showed non-significant decrease in hepatic phospholipid concentration compared with controls [P> 0.05] respectively. However liver phospholipid concentrations of albino rats fed with tannia supplemented diets were significantly higher than those of albino rats fed with taro supplemented diets [P< 0.05]. Generally, the taro diet supplementation elicited lower body weight gain, with better feed intake among the experimental animals. However diet supplementation with tannia and taro can be recommended for both human and livestock consumption for weight maintenance, as well as for reduction and maintenance of low hepatic lipid profile
Asunto(s)
Animales de Laboratorio , Colocasia , Colesterol , Fosfolípidos , Dieta , Hígado , RatasRESUMEN
The effects of Xanthosoma sagittifolium [tannia] and Colocasia esculenta [taro] based diets on hepatic cholesterol and phospholipid levels in albino rats were studied. Fifty albino rats randomly distributed into 5 groups [I-V] of 10 rats each, were respectively fed grower's mash as the control diet and 25% tannia, 50% tannia, 25% taro and 50% taro supplemented diets respectively for a period of 30 days. Hepatic cholesterol and phospholipid concentrations were measured spectrophotometrically. There were statistically significant decreases in hepatic total and esterified cholesterol concentration in rats fed with the taro and 50% tannia supplemented diets when compared with those on control diet [P<0.05]. However; only rats fed with 50% tannia supplemented diet showed significant decrease in hepatic free cholesterol compared with controls [P<0.05]. Rats fed with tannia supplement showed non-significant elevation in hepatic phospholipid concentration, while those fed with taro supplement showed non-significant decrease in hepatic phospholipid concentration compared with controls [P>0.05] respectively. However, liver phospholipid concentrations of albino rats fed with tannia supplemented diets were significantly higher than those of albino rats fed with taro supplemented diets [P<0.05].Generally, the taro diet supplementation elicited lower body weight gain, with better feed intake among the experimental animals. However, diet supplementation with tannia and taro can be recommended for both human and livestock consumption for weight maintenance, as well as for reduction and maintenance of low hepatic lipid profile