Anti-inflammatory activity of cimetidine, AH2 receptor antagonist

Cimetidine, a H2 receptor antagonist has been screened for anti-inflammatory activity against carrageenin, 5-hydroxytryptamine [5-HT], formaldehyde, nystatin and croton oil-induced inflammatory models representing acute, subacute and chronic inflammations. Aspirin was used as a standard drug for comparison. The drugs were administered orally. Cimetidine has shown significant anti-inflammatory response in carrageenin - induced and 5-HT - induced oedema models, an insignificant response in formaldehyde - induced oedema while no response in nystatin - induced and croton oil - induced inflammatory models. Cimetidine has prevented ulceration of aspirin when administered concomittantly