[Effect of long-term continuous methimazole treatment of thyrotoxicosis: comparison with radioiodine]

The major complication of radioiodine therapy for thyrotoxicosis is hypothyroidism, the long-term management of which is often problematic. In this study, the long-term effects of continuous methimazole [MMI] therapy are investigated. One hundred and thirty-two patients, aged between 36-66 years, with Graves recurrence, were semi randomly randomized in 2 groups for continuous antithyroid and radioiodine treatment. The number of thyroid dysfunctions in each patient were recorded and serum TSH, FT4, Anti TPO, TRAb, FBS, HOMA IR, and lipid profiles were measured. Bone mineral density and echocardiography were performed. There was no significant differences in age, duration of symptoms and thyroid function between the 2 groups. No serious complications occurred in the MMI group and no difference in any of parameters was seen between groups 1 and 2. Goiter rate and anti TPO concentration were higher in group 1 than in group 2. Serum triglycerides and cholesterol were increased in group 2 as compared to group 1. Bone mineral density was more reduced in group 2, especially in the spine. Echocardiography showed diastolic dysfunction in group 2 as compared to group 1. Some parameters in neuro-pschyciatric evaluation were significantly better in the MMI group, as compared to the radioiodine one. Considering it is a safe treatment and has fewer complications, methimazole is another option for patients with recurrent Graves', who do not wish to use radioiodine

Survey of prevalence of ornithobacterium rhinotracheale in broiler farms affected with respiratory disorders in Markazi province

Respiratory diseases are considered as common disorders in broiler farms. Over the past decade a pleomorphic gram negative bacteria which isolated from broilers with respiratory diseases now calls ornithobacterium rhinotracheale. In this study, samples from trachea and lung collected from chicken with clinical respiratory signs in 173 broiler farms and then subjected on bacterial culture. The bacteria were identified using specific biochemical tests. The ornithobacterium rhinotracheale was isolated from 17 samples [9/8%] in addition sensitivity of isolated bacteria against different antibiotic was examined with kerby- bauer method. As results most of the isolates were sensitive to doxycycline antibiotic. Therefore, biosecurity and vaccination in bieeders is recommended