RESUMEN
A neonate with glucose-6-phosphate dehydrogenase [G6PD] deficiency and Arnold-Chiari Malformation [ACM] type 2 underwent lumbar meningomyelocele [MMC] repair. Patients with G6PD deficiency are prone to develop haemolysis following any kind of oxidative stress and in ACM, there is a disturbed cranio-spinal pressure relationship. The neonate was managed under general anaesthesia with propofol for induction as well as for maintenance along with fentanyl and oxygen-nitrous mixture
RESUMEN
Pharmacophore mapping investigations were carried out on a dataset of 36 pyrazole derivatives that demonstrate antiproliferative activity in human ovarian adenocarcinoma A2780 cells. Pharmacophore modeling is a powerful tool for activity prediction of the ligands. Three point pharmacophore model was developed with two hydrophobic groups, one hydrogen bond acceptor, as pharmacophoric features. The pharmacophore hypothesis AHH.14 with R[2] value 0.909 yields a 3D-QSAR model which is statistically significant and best pharmacophore hypothesis. External validation of AHH.14 was performed by activity prediction of test set molecules with squared predictive correlation coefficient of 0.875 was observed between experimental and predicted activity values of test set molecules. AHH.14 pharmacophore model may offer potential for the design of antiproliferative agents via development of lead structures