Accuracy and validity of common dental terms using chat GPT model: a cross-sectional study

Background: Chat generative pre-trained transformer, an artificial intelligence chatbot can generate text-based content for information purpose. This study aims to find the accuracy and reliability of the chat GPT generated definitions for 30 common dental terms. Methods: A 15 current dental teaching staffs grading from Professors and Readers of various specialities participated in this study. They graded the chat GPT generated terms on a 5-point Likert scale (1- Strongly disagree, 2- Disagree, 3- Neutral, 4- Agree, 5- Strongly disagree). Scores were obtained and descriptive statistics was done and compared using Mann-Whitney U test. Results: Among 30 dental terms, 13 terms which were generated from the chat GPT model were found to be more appropriate when compared to text book definition. On comparison of reviewers’ perceptions for accuracy of definitions generated from chat GPT compared with text book definitions in which among the 30 dental terms, 9 terms were found to be statistically significant (p<0.05*). Conclusions: Chat GPT is a potential tool for answering knowledge based questions with equal vigor in the field of dentistry. Moreover, the accuracy of Chat GPT to solve questions in dentistry has a relational level of accuracy.

A clinical study of drug –drug and drug-food study interactions on the management of hyperlipidemic disease: simvastatin, ezetimibe and omega-3-fatty acids.

This study was designed to investigate the effects of combination of ezetimibe, simvastatin and omega-3-fatty acids on lipoproteins in patients with mixed dyslipidemia. Among the 102 patients were screened 98 who met the inclusion and exclusion criteria after 6 weeks on a strict diet therapy were grouped into four treatment groups (2 patients left out in between). The inclusion criteria were mixed dyslipidemia with a high triglyceride level (200-499 mg per 100 ml) and a total cholesterol level more than 200 mg per 100 ml. Present study was conducted on dyslipidemic patients receiving ezetimibe (10 mg) alone, simvastatin (20 mg) alone, omega-3-fatty acids (4 g) alone and combination of simvastatin (20 mg) and ezetimibe (10 mg) and omega-3-fattyacids (4g) daily for 12weeks. After 12 weeks treatment (Tc, LDL)was found decreased, Tg level reduced significantly and HDL level increased in the combination therapy (Simvastatin, ezetimibe and omega-3-fattyacids) than monotherapy. From the result it is concluded that combination therapy of these three may be considered as an optimal treatment option for patients with mixed dyslipidemia.

Study of drug-drug interaction on the management of hyperlipidemic disease: Simvastatin and ezetimibe.

This study was designed to investigate the effects of combination of ezetimibe and simvastatin on lipoproteins in patients with mixed dyslipidemia. Among the 482 patients screened 465 who met the inclusion criteria after 6weeks on a strict diet therapy were grouped into three treatment groups. The inclusion criteria were mixed dyslipidemia with a high triglyceride level (200-499 mg per 100ml) and a total cholesterol level more than 200mg per 100ml. Retrospective study was conducted on dyslipidemic patients receiving ezetimibe (10mg) alone, simvastatin (20mg) alone, and combination of simvastatin (20mg) and ezetimibe (10mg) daily for 24weeks. After 24 weeks treatment,(Tc, Tg, LDL)was found significantly decreased and HDL level increased in the combination therapy (Simvastatin and ezetimibe) than monotherapy. From the result it is concluded that combination therapy may be considered as an optimal treatment option for patients with mixed dyslipidemia.

Validation of Pregabalin in Human Plasma by LCMS Method.

An accurate and precise developed LCMS method was validated for the determination of pregabalin in human plasma. Validation was carried out according to US FDA guidelines. Validation data showed were within the limits. No matrix effect was found in different sources of human plasma tested. Dilution integrity, Lower limit of quantitation were also within the limit. The Mean extraction recovery of pregabalin was satisfactory.

Surgery for ossification of the posterior longitudinal ligament of the cervical spine.

The authors present their surgical experience with fifty seven cases of ossification of the posterior longitudinal ligament (OPLL) of the cervical spine, operated between January 1992 and January 1999. Continuous OPLL was seen in the majority of patients (40/57). Posterior decompressive surgery was performed in 18 patients, a median corpectomy and excision of the OPLL in 28 and anterior segmental decompression in 11 patients. One patient had a transient weakness of muscles supplied by the C5 myotome following a C4-C5 corpectomy. 84.2% of the patients showed improvement by at least one grade at the time of discharge. 92.8% of patients who underwent a corpectomy improved in the immediate post-operative period as compared to 90.9% of those who underwent an anterior segmental decompression and 83.3% of those who underwent a posterior decompressive procedure. 97.7% of the 44 patients followed-up between one and five years showed neurological improvement. Thirty-two patients (72.7 %) had regained normal or near normal neurological function and returned to their jobs. Good results were obtained when the surgical approach and the procedure adopted were individualised.