Estimation of left ventricular function in ventricular septal defect by tei index

Background: Ventricular Septal Defect (VSD) is one of the most common congenital cardiac diseases, accounting for 20%, and affects the left ventricular function. There is no study on the application of Tei index to evaluate left ventricular function in patients with VSD in Vietnam. Objective:To assess left ventricular function in ventricular septal defect by Tei index. Subject and Method: A cross-sectional descriptive study that involves 35 patients of VSD with an average age of 15.77+/-10.41 (A group: 19 patients of VSD with systolic pulmonary artery pressure (PAPs) < 40 mmHg and B group: 16 patients of VSD with PAPs>=40mmHg and control group: 30 normal volunteers). Results: Tei index for estimation of left ventricular function is higher in the VSD (0.50+/- 0.18) than the control (0.37 +/- 0.03) with p < 0.01, exponentially more in the VSD with PAPs >=40mmHg (0.64 +/- 0.15; p<0.01). Conclusion: Left ventricular function is worse in VSD patients in comparison to the healthy people.

Preliminary study on the effectiveness of oral ibuprofen in treating persistent Patent Ductus Arteriosus (PDA) for respiratory distress of premature neonates

Background: PDA is an especially common pathological condition in premature neonates because of the anatomical structural immaturity of the cardiovascular system. There are evidence for the effectiveness of ibuprofen for closing persistent ductus arteriosus, with few adverse effects. Objectives: To determine whether oral ibuprofen treatment is effective and safe in the closure of PDA in premature infants with respiratory distress syndrome. Subjects and methods: The prospective study was conducted on premature newborns with PDA who were presented at the Department of Neonatology, National Hospital of Pediatrics. Results: A total of 32 neonates were eligible for the study. Ductal closure was achieved in 22 newborns (68.6%), the ductus was persistent after 6 doses in 8 cases (25.1%), 2 newborns (6.3%) suffered from ductal reopening after closure (after 1 and 2 doses). PDA closure was achieved with 1 dose of ibuprofen in 7 cases, 2 doses in 9, 3 doses in 4 and more than 4 doses in 4 cases. The survival rate was 81.2% (26 out of 32). 6 patients (18.8%) died from severe respiratory distress and very low birth weight (2 cases), Klebsiella sepsis (4 cases). Mortality is higher in the closure failure group (p<0.05). Conclusions: Oral ibuprofen suspension can be considered as an effective and safe alternative for PDA closure in premature newborns. Larger comparative studies is required to confirm these results.

Drug therapy before during and after intervention for coronary disease

Before an intervention for coronary disease, it should consider thoroughly the medical history of patients, tests and used drugs. This paper introduced some drug for using before, during and after intervention of the coronary disease including analgesics, sedative, anti allergy with opaque compounds and drug, platelet anti-aggregation, gluco-protein receptor inhibitors, anti-coagulant, anti-clotting agents, myocardial is chimes preventive agents. This paper also presented some complications during and after intervention for coronary disease such as postoperative coronary occlusion, coronary spasm, and thrombosis. It should be monitored after intervention and drugs using.

Left ventricular hypertrophy in hypertension

This study introduced the deep researches on the diagnosis of left ventricular hypertrophy by electrocardiogram (ECG) and cardiac ultrasound as well as treatment of the left ventricular hypertrophy due to hypertension including drug therapy and non drug therapy