RESUMEN
The monoclonal antibody RL23/36 has been shown to discriminate normal from malignant hepatocytes in man. In frozen sections of liver tissue from 25 Thai patients without hepatocellular carcinomas, the antibody reacted strongly and preferentially with hepatocytes. Reactivity with 7 hepatocellular carcinomas was invariably abnormal, being totally absent in 5 and partially lost in 2. This discrimination was superior to that achieved with Ca1 and 791T/36 monoclonal antibodies. In 2 cases of hepatocellular carcinoma, binding of RL23/36 to associated apparently non-malignant hepatocytes was abnormal, being absent in one and partially lost in the other. These data show that RL23/36 detects an antigenic determinant which is lost during malignant transformation of human hepatocytes, sometimes before the development of frank malignancy.
Asunto(s)
Animales , Anticuerpos Monoclonales/diagnóstico , Biopsia , Carcinoma Hepatocelular/patología , Diferenciación Celular , Humanos , Neoplasias Hepáticas/patología , Ratas , Coloración y Etiquetado , TailandiaAsunto(s)
Adenoma de los Conductos Biliares/tratamiento farmacológico , Adulto , Neoplasias de los Conductos Biliares/tratamiento farmacológico , Carcinoma Hepatocelular/tratamiento farmacológico , Femenino , Humanos , Levamisol/uso terapéutico , Neoplasias Hepáticas/tratamiento farmacológico , Masculino , Persona de Mediana EdadAsunto(s)
Granuloma Eosinófilo/patología , Femenino , Gastrectomía , Gastritis/patología , Humanos , Persona de Mediana EdadAsunto(s)
Adolescente , Adulto , Anciano , Presión Sanguínea , Niño , Preescolar , Femenino , Humanos , Hipertensión/epidemiología , Lactante , Masculino , Persona de Mediana Edad , TailandiaAsunto(s)
Adulto , Fístula Arteriovenosa/diagnóstico por imagen , Arteria Celíaca/diagnóstico por imagen , Entamoeba histolytica , Femenino , Arteria Hepática/diagnóstico por imagen , Venas Hepáticas/diagnóstico por imagen , Humanos , Absceso Hepático Amebiano/diagnóstico por imagen , Masculino , Persona de Mediana EdadRESUMEN
Four patients who had obstructing carcinoma of the cystic duct and who presented themselves with enlarged and palpable gall bladders but without jaundice are reported. All patients came from endemic areas of opisthorchiasis and had evidence of Opisthorchis infection by peritoneoscopic and surgical findings. All but one had Opisthorchis eggs in the stool. The pathogenesis and management was discussed.