RESUMEN
Acute treatment of rabbits with pargyline (50 mg/kg, ip, 30 min before tolbutamide) significantly increased the elimination half life and AUC0-->infinity of tolbutamide resulting in prolonged hypoglycaemia. Similar treatment also prolonged the half life of antipyrine which is used as model drug to indicate hepatic microsomal enzyme activity in vivo confirming that pargyline treatment delayed the elimination of tolbutamide in rabbits by inhibiting its hepatic metabolism.
Asunto(s)
Animales , Antipirina/farmacocinética , Glucemia/análisis , Interacciones Farmacológicas , Femenino , Semivida , Hipoglucemia/inducido químicamente , Inyecciones Intraperitoneales , Masculino , Microsomas Hepáticos/efectos de los fármacos , Pargilina/administración & dosificación , Conejos , Tolbutamida/administración & dosificaciónRESUMEN
The influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide was studied in rabbits. Ranitidine treatment (15 mg/kg, po, twice daily for one week) enhanced the hypoglycaemic activity of glibenclamide (40 micrograms/kg, po) while it has not altered either the hypoglycaemic activity or pharmacokinetics of tolbutamide (40 mg/kg, po) in rabbits.