Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form

Fixed dose combination tablets containing ambroxol HCI and cetirizine HCI are clinically used as mucolytic and antiallergic. Several spectrophotometric and HPLC methods have been reported for simultaneous estimation of these drugs with other drugs. The drugs individually and in mixture obeys Beer's law over conc. range 1.2-4.4 micro g/mL for cetirizine HCL and for ambroxol HCL 15-52 micro g/mL at all five sampling wavelengths [correlation coeff. Well above 0.995]. The mean recoveries from tablet by standard addition method were 100.18% [ +/- 2.4] and 100.66% [ +/- 2.31]. The present work reports simple, accurate and precise spectrophotometric methods for their simultaneous estimation from tablet dosage form