study of atypical cholinesterase in offspring's of a heterozygous couple

Deficiency of plasma cholinesterase [ChE] was detected in several members of the family tested on suspicion of genetic modification of enzyme structure. Prolonged apnea following administration of suxamethomum [succinylecholine] was due to low levels of cholinesterase from homozygote for atypical gene [E[1a], E[1a]]. Screening of immediate relations showed atypical genetic response in cholinesterase [ChE] activity in offsprings of a heterozygous couple. [ChE [E[1a], E[1u]]. As our data are in accordance with results obtained by other investigators, this observation cannot be regarded as exceptional

clinical trial of intraoperative normovolemic haemodilution and autotransfusion in neurosurgery

A study of intraoperative normovolaemic haemodilution and autotransfusion was carried out in 20 patients undergoing neurosurgery to determine the safety and efficacy of the procedure. After induction of anaesthesia two units of blood were collected from the patients and in exchange equal volume of 3.5% polygeline [Haemaccel] was infused, total blood loss, haemoglobin, haematocrit and electrolyte changes were compared with a control of twenty neurosurgical patients without haemodilution. Only 10% patients in the study group required homologous blood transfusion compared to control group in which 85% patient did so