Effect of xylene on the skin of albino rats

To evaluate the effect of xylene on the skin, 30 albino rats were selected and divided into three groups, ten animals each. Group B showed loss of hair, degeneration of horny layer and erosions in their limbs. The epidermal cells showed vacuolated hypochronic cytoplasm and pyknotic nuclei. Areas of congestion, cellular infiltration, destructed hair follicles and spongiosis were observed in the dermis. Group C showed signs of recovery and healing within 14 days of cessation of exposure. These data proved that xylene was irritant to the skin and can cause contact dermatitis which should be avoided by suitable protection methods when using xylene