Immunohistochemical localization of s-100 protein in salivary gland tumours

Twenty-two biopsy specimens of salivary gland tumors were examined immunohistochemically for S-100 protein localization. These included nine pleomorphic adenomas, four adenolymphomas, one basal cell adenoma, five mucoepidermoid carcinomas, two adenoid cystic carcinomas and one acinic cell carcinoma. S-100 protein was found in myoepithelial cells and cells in myxoid and chondroid areas in pleomorphic adenomas. In adenolymphomas, mucoepidermoid carcinomas and adenoid cystic carcinoma cases, No S-100 activity was present either in the epithelial component or in the stroma of these specimens. So, it was demonstrated from this study that myoepithelial cells play a major role in the histogenesis of salivary gland tumors, especially pleomorphic adenomas

Immunohistochemical localization of carcinoembryonic antigen in endocervical glandular lesions

Ten cases of microgl and ular hyperplasia and seven cases of adenocarcinoma of endocervical origin were studied by peroxidase- antiperoxidase method [PAP] for the presence of carcinoembryonic antigen [CEA]. Nine of the ten cases of benign lesions were negative and one was focally positive. Five of the seven adenocarcinomas were widely positive and two were focally positive. The results suggested that extensive immunohistochemical positivity for CEA in endocervical gl and ular lesions is indicative of malignancy