Two new imidazole alkaloids from leucetta chagosensis sponge

Chemical investigation of the sponge Leucetta chagosensis, has led to the isolation of two new imidazole alkaloids, methyldorimidazole [1], preclathridine B [2] along with the know compounds naamine E [3] and leucettamine C [4]. The structures of the newly compounds [1 and 2] were elucidated by employing spectroscopic techniques [[1] HNMR, MS and UV]. The structures of the known compounds 3 and 4 were determined by comparison of their [1] HNMR and Mass spectroscopic data with published values

Bromopyrrole alkaloids from marine sponge Agelas oroides

Following a bioassay-guided approach four bromopyrrole alkaloids, oroidin [1], 4,5-dibromopyrrole-2-carboxanijde [2], 4,5-dibromopyrrole-2-carboxylic acid [3] and 4,5-dibromopyrrole-2-[N methoxymethyl] carboxamide [4], were isolated from the bioactive ethyl acetate extract of the tropical marine sponge Agelas oroides. The structures of the isolated compounds were elucidated using their UV, NMR [I D and II D] and mass spectra. Fish feeding, brine shrimp, cytotoxic activity against L5178Y and Hela cell lines, protein kinase inhibition test and the antimicrobial activities for the isolated compounds were investigated. The fish-feeding assay showed that the total alcoholic extract was highly active and the major compound, oroidin, is responsible for this activity [in concentration of 80 mg/10 ml]