Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Intervalo de año
1.
Braz. j. infect. dis ; 24(2): 180-187, Mar.-Apr. 2020. tab, graf
Artículo en Inglés | LILACS, ColecionaSUS | ID: biblio-1132429

RESUMEN

ABSTRACT The accuracy of commercially available tests for COVID-19 in Brazil remains unclear. We aimed to perform a meta-analysis to describe the accuracy of available tests to detect COVID-19 in Brazil. We searched at the Brazilian Health Regulatory Agency (ANVISA) online platform to describe the pooled sensitivity (Se), specificity (Sp), diagnostic odds ratio (DOR) and summary receiver operating characteristic curves (SROC) for detection of IgM/IgG antibodies and for tests using naso/oropharyngeal swabs in the random-effects models. We identified 16 tests registered, mostly rapid-tests. Pooled diagnostic accuracy measures [95%CI] were: (i) for IgM antibodies Se = 82% [76-87]; Sp = 97% [96-98]; DOR = 168 [92-305] and SROC = 0.98 [0.96-0.99]; (ii) for IgG antibodies Se = 97% [90-99]; Sp = 98% [97-99]; DOR = 1994 [385-10334] and SROC = 0.99 [0.98-1.00]; and (iii) for detection of SARS-CoV-2 by antigen or molecular assays in naso/oropharyngeal swabs Se = 97% [85-99]; Sp = 99% [77-100]; DOR = 2649 [30-233056] and SROC = 0.99 [0.98-1.00]. These tests can be helpful for emergency testing during the COVID-19 pandemic in Brazil. However, it is important to highlight the high rate of false negative results from tests which detect SARS-CoV-2 IgM antibodies in the initial course of the disease and the scarce evidence-based validation results published in Brazil. Future studies addressing the diagnostic performance of tests for COVID-19 in the Brazilian population are urgently needed.


Asunto(s)
Humanos , Neumonía Viral/diagnóstico , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Infecciones por Coronavirus/diagnóstico , Técnicas de Laboratorio Clínico/normas , Betacoronavirus/inmunología , Anticuerpos Antivirales/sangre , Orofaringe/virología , Neumonía Viral/inmunología , Neumonía Viral/epidemiología , Brasil/epidemiología , Modelos Logísticos , Oportunidad Relativa , Nasofaringe/virología , Curva ROC , Sensibilidad y Especificidad , Infecciones por Coronavirus/inmunología , Infecciones por Coronavirus/epidemiología , Técnicas de Laboratorio Clínico/métodos , Pandemias , Betacoronavirus/aislamiento & purificación , Prueba de COVID-19 , SARS-CoV-2 , COVID-19
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA