effect of snake venom metalloproteinase/disintegrin like activity on liver of albino white mice

This is a study on the effect of snake venom metalloproteinase/ Disintegrin like action [SVMP] purified from Cerastes cerastes venom on expression of TNF-alpha, and Heme-oxygenase-1 in white mice liver tissue injected intraperitoneally with the purified fraction. Hepato-protective effect of the fraction against some hepatotoxins as CCU was investigated histo-pathologically. This hepatoprotection coincides with expression of TNF-alpha and HO-1 genes in liver tissue. This study is supported by grant no. 28 from Professor Dr. M. F. EL-Asmar