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Objective:To construct the knowledge base of Tibetan medicine prescriptions and explore to standardize the names of Tibetan medicine prescriptions. Method:By using the concept of "man-machine combination"，through the construction of Tibetan medicine terminology glossary （data sources： national drug standards，local drug standards，text classics on Tibetan medicines，etc.），the terminology glossary of Tibetan medicine prescriptions was mined. Upon its combination with expert review，the text association between Tibetan medicine prescriptions and various drug standards and dictionaries was constructed，and the standardization methods and techniques of prescription drug names were explored. Result:In this paper，the Tibetan medicine prescriptions approved for marketing in China were taken as the research object，and various inconveniences caused by the inconsistency between the names of prescriptions and the names of medicinal herbs were revealed. This paper also discussed the design ideas on name standardization of Tibetan medicines from three levels： text association，optimization of evaluation methods，and formation of expert decision-making system. We put forward a five-in-one （screening， evaluation， reviewing， fixing， and renewing） research model of Tibetan medicine name standardization. The construction，functions and advantages of the database and thesaurus of Tibetan medicine prescriptions were described in detail， and in combination with the text notes， association between the standard medicinal materials and the prepared prescriptions was then established. Conclusion:The text association method in this paper can accurately reflect the nonstandard names of Tibetan medicine prescriptions. Combined with expert review，it can be， to a certain extent， extended to the standardization of herb names in prescriptions with large scale of or more complex network structures.
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Objective:In view of the complexity of the "Prescription-Formula-Dosage-Property" relationship of Tibetan medicine and the outstanding common relationship，it is difficult to reveal the hidden and specific rules of clinical medication of Tibetan medicine. Method:Based on the attribute partial order structure and the vector structure model of "Ro-Nus-Zhu-Rjes"（Taste，Post-Digestive Tastes and Potency），clustering analysis and other methods and software，this study analyzed the "Prescription-Formula-Dosage-Property" relationship of 184 commonly used prescriptions in the 1995 edition of the standards issued by the Ministry of Tibetan medicine（SIMTM）. Result:Among them，the analysis of the relationship between prescription and formula found that 11 prescriptions with the largest common attribute，such as Chebulae Fructus and Carthami Flos，were the key components of classification and compatibility，which could effectively classify the 8 kinds of prescriptions for the treatment of lung disease，tripa disease and blood fever. Among them，the san Yin and auxiliary viscera function prescriptions，such as Sanguotang powder and Liuwei Liangyao powder，had the strongest commonality. According to the analysis of relationship between formula and dosage ，the dosage of Chebulae Fructus，Carthami Flos，pomegranate seed，Phyllanthi Fructus was the highest，which suggested that these drugs were often used as primary drugs，while the Liuwei Liangyao powder，such as Amomi Fructus Rotundus and Tsaoko Fructus，had a higher frequency but a lower dose，which mainly played a role in regulating the overall drug property of the prescription and protecting the viscera. The Tibetan medicine-specific drugs including Moschus，Bovis Calculus，and Zhaxun，which were used in a high frequency but very low dose，had the effect of enhancing the drug property and guiding the affected part. According to the analysis of the relationship between dosage and property，there were many prescriptions belonging to cool nature，accounting for 75.6%. It was found that 67 prescriptions did not conform to the efficacy due to their different dosage. Conclusion:There are many common components and common usages in Tibetan medicine prescriptions. If these common associations are not treated，it will lead to the result that all diseases take these common associations as the core，but the hidden key factors cannot be solved. Therefore，it is necessary to pay attention to sensitivity and specificity at the multi-dimensional level of "prescription-formula-dosage-property"，so as to reveal the clinical medication thought of Tibetan medicine more effectively.
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Ro Nus ZhurJes theory is the core content of Tibetan medicine,it can be divided into "taste performance"(Ro Yi Nus Pa) and "essential performance"(Ngo Bovi Nus Pa),and "taste performance" is divided into six tastes,eight properties,three tastes after digestion,seventeen effects and so on."Essential performance" is divided into eight kinds,including odor efficacy,sources efficacy,color efficacy,et al.Form bearing relationships that "taste performance" and "essential performance",the butt welding joins the three-factors and twenty characteristics of disease,it is the theoretical basis of Tibetan medicine from collection and processing,from formula to finished product. It is also the main method for the evaluation of drug performance by Tibetan medicine.Many classic Tibetan medicine prescriptions are compatible under the guidance of Ro Nus ZhurJes.However,at present,the research of Tibetan medicine mainly concentrates on the chemical composition and pharmacological mechanism.It is seldom studied from the Ro Nus ZhurJes theory of Tibetan medicine.It is difficult to find the core rules and effect of Tibetan medicine.Therefore,based on the ancient literature of Tibetan medicine,this paper combs the theory of Tibetan medicine property,explains the six tastes,three tastes after digestion,and seventeen effects of Tibetan medicine function in three-factors,twenty characteristics and other diseases attributes,in order to provide theoretical reference for the study of drug properties of Tibetan medicine.
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“Ro Nus ZhurJes” theory is the core content of Tibetan medicine property theory, and also the core compatibility law of Tibetan medicine. It takes six tastes of medicine as the surface medicinal property, three tastes after digestion by "three gastropyretie" as the inner medicinal property, eight properties and seventeen effects as the deep medicinal property, and its essential property is the special medicinal property, forming a multi-level medicinal property theory, but its internal structure still needs to be unified and sorted out, clinical practicability needs to be further improved. In this paper, literature mining, Tibetan medicine theory, vector structural model, K-means clustering analysis, Gephi 0.9.2 visualization and other methods were used to sort out the theory of Tibetan medicinal properties. It was found that the inherent structure of Tibetan medicine properties had the multi-dimensional structural characteristics of "seven medicinal properties+three characteristics", and that the same medicinal properties would overlap, while the opposite medicinal properties would offset and could be expressed by vectors. Therefore, the vector structural model of "Ro Nus ZhurJes" of Tibetan medicine was proposed in this paper. Taking twenty-five-flavor Yuganzi powder(skyu-ru-nyer-lnga) and 92 commonly used Tibetan medicine prescriptions as examples, the rates of single prescription with seventeen effects and multiple prescriptions acting on three factors were analyzed. The model analysis results were highly consistent with the clinical efficacy, and the main diseases were the same, which showed that this model had a high degree of fitting and interpretation. It could effectively and intuitively quantify the properties of Tibetan medicine prescriptions and uncover the complex hidden knowledge of Tibetan medicine theory. In the future, the vector structural model of "Ro Nus ZhurJes" will be applied to analyze the classical prescriptions of Tibetan medicine, and the fitting evaluation and modification optimization will be carried out continuously in order to improve the practicability of theory of Tibetan medicine property in the big data environment and provide methodological reference for the quantification of medicinal property of Tibetan medicine prescriptions.