Progress in basic research of colorectal liver metastases / 国际外科学杂志

Liver metastases is the independent risk factor of prognosis of colorectal cancer.In this article we summarized the research about the mechanism of colorectal liver metastases over the latest five years.Studies showed that the specific cell adhesive interaction in metastatic target organs plays an important role in metastases. The metastatic procedure call be roughly assigned to:escape,adhesion,invasion,survival and proliferation.The interactions between tumor cells and nonparenchymal cens in the liver lead to tumor growth.Tumor micro-environ ment is characterized by the lack of oxygen,inflammation,immune suppression,meanwhile,the role played by cell factors in the tumor micro-environment can not be ignored.