RESUMEN
With the development of phamacogenomic and molecular biology, it has been revealed that the curative effect of non-small-cell lung cancer (NSCLC) is closely related to tumor molecular markers. Predictive biomarkers in NSCLC patients, including ERCC1, BRCA1, hMLH1, hMSH2, RRM1, β-tubulin, TS,EGFR and K-ras, can predict individual patient's response to chemotherapy or targeted therapy, making individualized therapy be possible.
RESUMEN
Bisphosphonates have shown direct anti-tumor and anti-angiogenesis effects, but the exact mechanism has not yet been elucidated. Based on the existing findings, some mechanisms related to the inhibition of vascularization has been proposed. First, bisphosphonates inhibit the differentiation of endothelial progenitor cells by interfering with the key enzyme in the mevalonate pathway which plays an important role in the prenylation of small G-proteins. Second,bisphosphonates impair the proliferation,adhesion and migration of endothelial cells. Last, bisphosphonates are able to regulate secretion of cytokines which are involved in angiogenesis and inhibit the functions of angiogenesis-related genes.