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Artículo en Chino | WPRIM | ID: wpr-1038774

RESUMEN

Objective @#To explore the independent risk factors affecting the prognosis,and to construct a nomogram model predicting overall of patients with rectal cancer at T1 and T2 stage.@*Methods @#Retrospective analysis was made on the data of 353 patients diagnosed as rectal cancer,who received the radical rectal resection.The collect- ed data were as follows : age,body mass index (BMI) ,carcinoembryonic antigen ( CEA) ,tumor size,histological type,T stage,N stage,tumor location and number of lymph nodes detected,which were used to perform Kaplan- Meier curve and Log-rank test for univariate analysis and Cox regression for multivariate analysis.The nomogram model was established to predict the overall survival of patients. @*Results @#Age≥60 years,Mucinous adenocarcino- ma,poorly differentiation ,T2 stage ,lymph node metastasis ,BMI ≥25 kg / m2 ,CEA ≥5 μg / L and number of lymph nodes detected <12 were associated with overall survival of patients with rectal cancer at T1 and T2 stage (all P<0. 05) .Cox regression showed that age≥60 years,T2 stage,mucinous adenocarcinoma,lymph node me- tastasis,CEA≥5 μg / L,BMI ≥25 kg / m2 and lymph node detection number <12 were independent risk factors. Based on the above independent risk factors,the nomogram model was constructed,and the predicted curve was in good agreement with the actual survival curve ( C-index = 0. 779) .@*Conclusion @#Age≥60 years,T2 stage,mucin- ous adenocarcinoma,lymph node metastasis,CEA≥5 μg / L,BMI≥25 kg / m2 and the number of lymph nodes de- tected <12 are independent risk factors ,and the nomogram established in this study can effectively predict the prognosis of patients with rectal cancer at T1 and T2 stage.

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