Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil: an epidemiological study

OBJECTIVES: To determine the characteristics, the frequency and the mortality rates of patients needing mechanical ventilation and to identify the risk factors associated with mortality in the intensive care unit (ICU) of a general university hospital in southern Brazil. METHOD: Prospective cohort study in patients admitted to the ICU who needed mechanical ventilation for at least 24 hours between March 2004 and April 2007. RESULTS: A total of 1,115 patients admitted to the ICU needed mechanical ventilation. The mortality rate was 51%. The mean age (± standard deviation) was 57±18 years, and the mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 22.6±8.3. The variables independently associated with mortality were (i) conditions present at the beginning of mechanical ventilation, age (hazard ratio: 1.01; p<0.001); the APACHE II score (hazard ratio: 1.01; p<0.005); acute lung injury/acute respiratory distress syndrome (hazard ratio: 1.38; p=0.009), sepsis (hazard ratio: 1.33; p=0.003), chronic obstructive pulmonary disease (hazard ratio: 0.58; p=0.042), and pneumonia (hazard ratio: 0.78; p=0.013) as causes of mechanical ventilation; and renal (hazard ratio: 1.29; p=0.011) and neurological (hazard ratio: 1.25; p=0.024) failure, and (ii) conditions occurring during the course of mechanical ventilation, acute lung injuri/acute respiratory distress syndrome (hazard ratio: 1.31; p<0.010); sepsis (hazard ratio: 1.53; p<0.001); and renal (hazard ratio: 1.75; p<0.001), cardiovascular (hazard ratio: 1.32; p≤0.009), and hepatic (hazard ratio: 1.67; p≤0.001) failure. CONCLUSIONS: This large cohort study provides a comprehensive profile of mechanical ventilation patients in South America. The mortality rate of patients who required mechanical ventilation was higher, which may have been related to the severity of illness of the patients admitted to our ICU. Risk factors for hospital mortality included conditions present at the start of mechanical ventilation conditions that occurred during mechanical support.

Vitamin D deficiency is independently associated with mortality among critically ill patients

OBJECTIVE: Studies suggest an association between vitamin D deficiency and morbidity/mortality in critically ill patients. Several issues remain unexplained, including which vitamin D levels are related to morbidity and mortality and the relevance of vitamin D kinetics to clinical outcomes. We conducted this study to address the association of baseline vitamin D levels and vitamin D kinetics with morbidity and mortality in critically ill patients. METHOD: In 135 intensive care unit (ICU) patients, vitamin D was prospectively measured on admission and weekly until discharge from the ICU. The following outcomes of interest were analyzed: 28-day mortality, mechanical ventilation, length of stay, infection rate, and culture positivity. RESULTS: Mortality rates were higher among patients with vitamin D levels <12 ng/mL (versus vitamin D levels >12 ng/mL) (32.2% vs. 13.2%), with an adjusted relative risk of 2.2 (95% CI 1.07-4.54; p< 0.05). There were no differences in the length of stay, ventilation requirements, infection rate, or culture positivity. CONCLUSIONS: This study suggests that low vitamin D levels on ICU admission are an independent risk factor for mortality in critically ill patients. Low vitamin D levels at ICU admission may have a causal relationship with mortality and may serve as an indicator for vitamin D replacement among critically ill patients. .

Mobilização do paciente crítico em ventilação mecânica: relato de caso / Mobilization of the critically ill patient in mechanical ventilation

A polineuropatia do paciente crítico (PNPC) é uma patologia relativamente comum no ambiente de terapia intensiva e ocasiona aumento do tempo de internação e de ventilação mecânica. Uma das causas relacionadas a essa patologia é a imobilização do paciente. O caso relatado é de um paciente de 18 anos, desnutrido, usuário de crack e com vírus da imunodeficiência humana e tuberculose pulmonar e intestinal. O paciente apresentou insuficiência respiratória necessitando de ventilação mecânica (VM) prolongada e PNPC associada. A fisioterapia com mobilização do paciente mesmo em uso de VM parece ter sido fundamental para a melhora da recuperação funcional associada à adequada nutrição e o tratamento das patologias apresentadas pelo paciente.

Polyneuropathy of critically ill patients, a relatively common condition in intensive care settings, increases length of hospitalization and mechanical ventilation. This disease is associated with patient immobilization. This report describes the case of an 18-year-old malnourished crack user and HIV-positive patient that had intestinal and pulmonary tuberculosis. The patient developed respiratory failure, which required prolonged mechanical ventilation, and polyneuropathy. Physical therapy with mobilization of the patient even while receiving mechanical ventilation, together with appropriate nutrition and treatment of the diseases, was instrumental in improving functional recovery.

Abordagem do paciente em estado de choque / Treating the patient in shock

Os autores fazem uma revisão sobre o paciente em estado de choque e sua abordagem, visando os aspectos fisiopatológicos, diagnósticos e seu manejo