An open multicenter study of the use of gatifloxacin for the treatment of non-complicated acute bacterial rhinosinusitis in adults

The bacteriological and clinical efficacy and the safety of gatifloxacin for the treatment of non-complicated acute rhinosinusitis was evaluated in 49 adult patients in an open-label multicenter study in Brazil. Patients under age 18, or with associated systemic diseases, were excluded. Diagnosis was based on symptoms, otorhinolaryngological examination, and X-rays of the sinus. At the first visit, all patients were treated with a single daily dose of 400 mg gatifloxacin for 10 days. Middle nasal meatus secretion was collected and sent for culture before and after treatment. Patients were all reevaluated at days 3 to 5; days + 1 to + 5 and 18 to 25 days + 7 to + 14 . Ninety three percent of the patients were considered clinically cured at the end of the treatment. The most frequent bacteria isolated were Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, and at the end of the treatment, presumed bacteriological eradication was observed in almost all patients. Adverse effects were observed in 19 of the cases, mostly mild and self limiting, including diarrhea, abdominal pain, nausea and vomiting. Treatment had to be interrupted in two cases. Gatifloxacin was found to be efficacious and safe for the treatment of acute rhinosinusitis in adults.

Histochemical study on the behavior of glycogen and total lipids in pregnant albino rats and their progenies treated with naphazoline

The histochemical study of 25 pregnant rats liver submitted to nasal drop instillation of saline and naphazoline at increasing concentrations, at the 19th day pregnancy, showed glycogen decrease and total lipid increase, only at a concentration of 1:1,000 of naphazoline. In this group occured also an increase of fetal liver lipids.

Comportamento da glicose, dos lipideos totais e da fosfatase acida no plasma de ratas prenhes, tratadas com diferentes doses de adrenalina, administrada sob a forma de gotas nasais. / The behavior of glucose, total lipids and acid phosphatase in the serum of pregnant rats treated with different dofes of adrenaline, administered under the formula of nasal drops

Vinte e cinco ratas prenhes, divididas em cinco grupos, foram tratadas durante todo o 19o. dia de gestacao, com instilacao de gotas nasais de 4 em 4 horas; o primeiro grupo considerado controle recebeu soro fisiologico e os restantes concentracoes crescentes de adrenalina. Apos 24 horas de tratamento, observou-se alteracao dos niveis de lipemia e de fosfatase acida no plasma, apenas quando foi empregado adrenalina em super dosagens, enquanto os niveis de glicemia mantiveram-se inalterados em todos os grupos

Estudo bacteriologico em sinusites maxilares. / Bacteriological study in maxillary sinusitis

Os autores apresentam um estudo bacteriologico em infeccoes sinusais, atraves de material colhido por puncao transmeatica inferior do seio maxiliar. Em 26 pacientes estudados, 27% das culturas foram negativas; 61,5% revelaram a presenca de 1 ou mais germes anaerobios, de forma isolada ou associada com germes anaerobios; e apenas 11,5% apresentaram somente germes anaerobios, unicos ou multiplos