Network pharmacology research on high frequency use of Tibetan medicine in treatment of HAPC based on data mining / 中国中药杂志

Based on the results of previous data mining,the mechanism of high frequency use of Tibetan medicine in the treatment of high altitude polycythemia(HAPC) was analyzed in this study by network pharmacology. The author obtained the high frequency use data on Tibetan medicine Terminalia chebula,Aucklandia lappa,Crocus sativus and Myristica fragrans for the treatment of HAPC by data mining in the previous period. The first five main active ingredients of each high frequency Tibetan medicine were screened out by reviewing comprehensive literature and TCMSP database. The potential targets of each medicine were screened by PharmMapper and Drug Bank database,and then the targets were imported into MAS 3. 0 database to obtain the corresponding path information. The KEGG database was used for path annotation and GO function enrichment analysis. Finally,Cystoscope 3. 4. 0 software was used to construct " compound-target-path" network for four high-frequency Tibetan medicines. Among them,the target points of four herbs related to HAPC were 16(T. chebula),20(A. lappa),20(C. sativus),and 15(M. fragrans). The common target points included BHMT,F2,ADH5,AKR1 C2,GSK3 B,INSR and PDE4 B,involving pathways related to T. chebula(17),A. lappa(17),C. sativus(24) and M. fragrans(14),and the common pathway was metabolism of xenobiotics by cytochrome P450. The results showed that high-frequency Tibetan medicine had common pathways and targets in treating HAPC,such as T. chebula,A. lappa,C. sativus and M. fragrans.The medicines could reduce hemoglobin and enhance immunity by mediating cell proliferation and oxidative stress,exerting anti-inflammatory effects and participating in regulating blood vessels,showing therapeutic effects for HAPC. In this study,the multi-component,multi-target and multi-pathway mechanism of Tibetan medicine in preventing and treating HAPC was analyzed from the information level,providing a useful reference for further study of Tibetan medicine in preventing and treating plateau diseases from the multi-dimensional perspective.

Application of spiral CT three-dimensional reconstruction in treatment planning of impacted teeth / 南方医科大学学报

<p><b>OBJECTIVE</b>To assess the value of three-dimensional (3D) reconstruction in treatment planning of impacted teeth.</p><p><b>METHODS</b>Thirty-two orthodontic patients with impacted teeth aged from 13 to 17 years were enrolled, including 15 with impacted maxillary canines, 8 with impacted premolars and 6 with second molar impaction and retention. All the impacted teeth were examined by spiral CT scan and 3D reconstruction to determine the 3D position of the tooth in relation to both the crown and root, and the proximity to the roots of other teeth. The data were used for treatment planning and determination of the suitable direction of the orthodontic forces, approaches of surgical exposure, and the position of the attachment to be bonded.</p><p><b>RESULTS</b>Normal occlusion was achieved for 15 patients with transposition maxillary canines and 5 with lower position premolar. Three malformed premolars were extracted after traction. For 9 patients with second molar impaction and retention, normal occlusion was achieved after extraction of the third molar or moving the first molar mesial.</p><p><b>CONCLUSION</b>Spiral CT scan and 3D reconstruction can accurately determine the 3D position of the impacted tooth and provide assistance in the treatment planning to achieve a higher success rate of orthodontic correction.</p>