RESUMEN
In this study, the effects of overvitamin D on cardiac lesions and the protective effects of zinc on them were studied. The results showed that cardiac MDA and calcium were significantly increased and cardiac lesions were characterized by nonspecial focal necrosis, accompaning with myofib-eral and interstitial calcification. Zinc could remarkably decrease cardiac MDA and calcium and the cardiac lesions were also much milder. It suggested that cardiac lesions induced by overvitamin D related to both cardiac lipid peroxide and calcium overload. It might be concluded that zinc could protect heart from overvitamin D intoxication.
RESUMEN
The effects of manganese on selenium content and glutathione peroxidaseactivity in blood and myocardium, and on selenium excretion in growing ratswere studied to ferret out the interaction of the two essential trace elements.Manganese dichloride (40mg/kg of MnCl2.4H2O) was administered daily to a group of 17 rats for 35 days intraperitoneally. An obvious increase in manganese content in serum and myocardium was induced. However, selenium levels in the two tissues of manganese-treated rats were significantly lower than the controls. From the 14th day on, glutathione peroxidase activities in whole blood of manganese-treated rats were below the controls, and on the 35th day, the activities of the selenium-containing enzyme in blood and myocardium were reduced by 29.33% (P
RESUMEN
In the present study, the effects of adriamycin on antioxidant enzymes, glutathione peroxidase (GSH-Px) and superoxide dismutase(SOD), and cardiac lesions were studied, furthermore, the protective influence of supplementation of copper and/or zinc on cardiac toxicity induced by adriamycin were investigated. Fourty four wistar rats weighing 130-160g were randomly divided into I-IV groups. All animals were fed on basic ration. The group I was given zinc sulphate 0.60mg/kg weight intraperitoneally once every third day for 49 days. The group I was given zinc 0.60mg + copper carbonate 0.14mg/kg weight intraperitoneally once every third day for 49 days. Groups I and I were given adriamycin 12mg/kg weight intraperitoneally. Group I was given adriamycin 12mg/kg weight intraperitoneally. Group IV was given physiological saline. The results suggested that the activities of GSH-Px and SOD were significantly decreased and cardiac lesions were characterized by numerous intracellular vesicles formed by dilation of the sarco-plasmic reticulum and lysis of myofiber accompanied by focal necrosis in group III. The activities of GSH-Px and SOD were apparently higher and cardiac lesions were much milder in the groups I and II, compared with those in the group VI.It may be concluded that trace elements (zinc and copper) can exert protective effects on cardiac lesions induced by adriamycin. Comparatively, much better results were observed in group I than that in group I.
RESUMEN
This article presents a discriminant equation for distinguishing children with Keshan disease from normals. The stepwise regressive discriminant equation is established by means of 10 variables including sex, age, and eight-element contents in hair based on 23 patients and 23 normal subjects. Variables finally entered to the discriminant equation are Mn, Cu, Zn, Ca, sex, and age as follows;Y = - 0.89 + 0.09XCu + O.OlXAn- 0.23XMn + 0.48XCa + 0.38Xsex- 0.05XageBy resubstitution test 95.7% accuracy is obtained. Applying the equation to the population (n=247) of endemic and non-endemic area, the accuracy of non-endemic is 100%. Thus, the equation may provide a basis for predicting endemic area or patients with Keshan disease.
RESUMEN
The dietary composition of inhabitants of the endemic and nonendemic areas, the epidemics of Keshan disease, and its clinical examinations from 14 counties in Heilongjiang, Hebei, Shanxi, Shantong, Shanxi, Sichuan, Yunnan and Xizhang provinces were investigated.The results revealed: (1) There were differences of the dietary sources between endemic and non-endemic inhabitants (difference of water-soil conditions); (2) The composition of diet between inhabitants of endemic and non-endemic areas were different; (3) There were differences of dietary composition of the inhabitants between peak year of incidence and ordinary year in endemic districts. The less the variety of diet the higher the incidence of the disease; the greater the variety of diet, the lower its incidence. The decrease of the incidence was closely related to the improvement of dietary conditions in endemic area.
RESUMEN
This article reported the results of eight series of animal experiments. In each series, the rats were divided into two groups: the experimental group was fed on corns and vegetables from endemic districts; the control group, from non-endemic districts. The composition of the foodstuffs was the same in the two groups. 375 albino rats were used in the experimental group, and 315 rats in the control group. The observation period was 8-13 weeks.The results showed that the incidence of myocardionecrosis had increased, the heart weight was comparatively larger, the mortality rate was higher, growth was stunted and the weights of the thymus and brown fat were lower than those of controls. The differences between experimental and control groups were stastistically singnificant. Such difference was not due to the composition of foodstuffs, but was closely related to the districts, from where the corns and vegetables were obtained. The results of these eight series of experiments were similar, and with very good reproducibility. It seemed that there were some myocardiac necroti-zing and growth inhibition factors in the corns and vegetables from the Keshan disease endemic districts.