RESUMEN
Objective To investigate the effects of metoprolol on Myocardial remodeling and cardiac function in type 2 diabetic patients with chronic heart failure.Methods 70 type 2 diabetic patients with chronic heart failure were randomly divided into treatment group and control group.Both groups were given conventional anti-heart failure treatment.The patients in the treatment group were administered with oral metoprolol.Two groups were treated for 12 weeks.The changes of cardiac function, left ventricular posterior wall thickness (LVPWTH), left ventricular end diastolic diameter ( LVEDD ) , left ventricular end systolic diameter ( LVESD ) , left ventricular ejection fraction ( LVEF) and E/A were observed before and after treatment in both groups.Results After treatment, the total effec-tiveness rate of the clinical curative effect in the treatment group was 85.71%, significantly higher than the control group (p<0.05).LVPWTH, LVEDD and LVESD decreased after treatment, while LVEF and E/A increased. These changes were more significant in the treatment group, with statistically significant difference between two groups ( p<0.05) .There was no significant effect of metoprolol on glucose and lipid metabolism in patients with type 2 diabetes mellitus.No serious adverse drug reaction was observed in both groups.Conclusion Metoprolol can reverse or delay left ventricular remodeling in type 2 diabetic patients with chronic heart failure, and can also improve cardiac function.