Differential diagnosis value of D-dimer before operation in renal oncocytoma and chromophobe renal cell carcinoma / 国际肿瘤学杂志

Objective:To explore the differential diagnosis value of preoperative D-dimer in renal oncocytoma (RO) and chromophobe renal cell carcinoma (Ch-RCC) .Methods:From January 2015 to April 2022 in the Second Hospital of Anhui Medical University, clinical data of 47 cases of rare renal tumors were collected. According to postoperative pathology, patients were divided into RO group (15 cases) and Ch-RCC group (32 cases). General clinical data and preoperative blood indicators were analyzed. Receiver operator characteristic (ROC) curve and area under the curve (AUC) were performed to evaluate the differential diagnosis value of D-dimer between RO and Ch-RCC.Results:There were no significant differences between two groups in gender ( χ2=0.41, P=0.522), age ( t=0.50, P=0.618), hypertension ( χ2<0.01, P=0.994), diabetes ( P=0.541), smoking history ( χ2=1.67, P=0.196), tumor laterality ( χ2=0.67, P=0.414). Besides, preoperative D-dimer was significantly higher in the Ch-RCC group [0.47 (0.29, 0.77) μg/ml] in comparison with RO group [0.21 (0.19, 0.27) μg/ml], with a statistically significant difference ( Z=4.44, P<0.001). In addition, there were no significant differences in hemoglobin ( t=-1.61, P=0.116), platelet ( t=0.26, P=0.800), leucocyte ( t=0.10, P=0.921), neutrophil ( t=-0.87, P=0.390), lymphocyte ( Z=0.82, P=0.418), monocyte ( Z=1.43, P=0.153), neutrophil-lymphocyte ratio ( Z=0.09, P=0.927), platelet-lymphocyte ratio ( t=0.42, P=0.676), and lymphocyte-monocyte ratio ( Z=-0.96, P=0.338) between Ch-RCC group and RO group. ROC curve analysis showed that when the cut-off value of preoperative D-dimer was 0.78 μg/ml, the AUC for differential diagnosis of RO and Ch-RCC was 0.90 (95% CI: 0.82-0.99, P<0.001), with a sensitivity of 0.78 and a specificity of 1.00. Conclusion:Preoperative level of D-dimer is significantly increased in Ch-RCC patients, which exhibits favourable preoperative differential diagnosis value between Ch-RCC and RO.

The effects of sulforaphane on proliferation , migration and invasion of human renal carcinoma cells and its mechanism / 安徽医科大学学报

Objective@#To investigate the effects of sulforaphane (SFN) on proliferation , migration and invasion of human renal carcinoma cells and its mechanism.@*Methods@#The cultured human renal carcinoma cells 786⁃O were divided into control group (0 μmol/L) and SFN group (5 , 10 , 20 μmol/L) . The activated proliferation of cells was detected by CCK⁃8 ; the effect of SFN on migration of 786⁃O cells was detected by scratch healing assay and Transwell cell migration assay; the effect of SFN on the invasion ability of 786⁃O cells was detected by Transwell cell invasion ability assay; Western blot and qRT⁃PCR were used to detect the effects of SFN on the expression of epithelial⁃mesenchymal transition (EMT) Ⅳrelated proteins and mRNA. The effect of SFN on the expression of NF⁃κB signaling pathway was detected by Western blot. @*Results@#After SFN treatment for 24 , 48 and 72 h , the proliferation activity of 786⁃O cells decreased with the increase of SFN concentration ; compared with the control group , the cell migration and invasion ability of SFN⁃treated group were significantly reduced ; with the increase of SFN concentration , the mRNA and protein expression levels of E ⁃cadherin in 786⁃O cells increased , while the mRNA and protein expression levels of N ⁃cadherin and Vimentin decreased ; the levels of NF⁃κB signaling pathway related protein phosphorylated p65 and phosphorylated IκBα decreased with the increase of SFN concentration. @*Conclusion@#SFN may inhibit the proliferation , migration and invasion of human renal carcinoma cells by regulating the EMT process of renal carcinoma through inhibition of NF⁃κB signaling pathway.

Effect of ginger and P6 acupressure on chemotherapy-induced nausea and vomiting: a randomized controlled study / Efeitos das compressões de acuponto de gengibre e Neiguan sobre náuseas e vômitos induzidos por quimioterapia: um estudo randomizado e controlado / Efecto del jengibre y la acupresión de P6 en las náuseas y vómitos inducidos por la quimioterapia: estudio controlado aleatorizado

ABSTRACT Objective: To evaluate the effect of ginger with P6 acupressure in preventing and treating chemotherapy-induced nausea and vomiting (CINV) in cancer patients. Method: A total of 172 participants were randomly divided into the control, ginger, acupressure, and joint groups, who were hospitalized in the Affiliated Hospital of Xuzhou Medical University from February and September 2022. The baseline characteristics, nausea, vomiting, and retching, benefit finding, functional living index-emesis, treatment satisfaction, and adverse reaction, were used in data collection. Results: No significant difference was found in benefit finding and adverse reactions among the four groups (P > 0.05). Ginger significantly improved delayed CINV and function living index-nausea (P < 0.05) but had no significant effect on acute CINV, retching, and delayed vomiting, functional living index-emesis, and treatment satisfaction (P>0.05). Acute nausea and retching, delayed nausea, vomiting, and retching, functional living index-emesis, and treatment satisfaction were effectively improved in the acupressure and joint groups (P < 0.05). Conclusion: Ginger with P6 acupressure may contribute to improving CINV in patients undergoing chemotherapy.

RESUMEN Objetivo: Evaluar el efecto del jengibre con acupresión P6 en la prevención y tratamiento de las náuseas y vómitos (nviq) inducidos por la quimioterapia en pacientes con cáncer. Método: Se dividió al azar A un total de 172 participantes en los grupos control, jengibre, acupresión y conjunto, que fueron hospitalizados en el Hospital afiliado de la universidad médica Xuzhou entre febrero y septiembre de 2022. En la recolección de datos se utilizaron las características basales: náuseas, vómitos y náuseas, hallazgo de beneficios, índice de vida funcional, satisfacción con el tratamiento y reacciones adversas. Resultados: No se encontró diferencia significativa en el hallazgo del beneficio y las reacciones adversas entre los cuatro grupos (P >0.05). El jengibre mejoró significativamente las nviq diferidas y el índice de vida funcional (nausea) de forma significativa (P < 0.05), pero no tuvo un efecto significativo en las nvi, las náuseas y el vómito diferidos, la emesis del índice de vida funcional y la satisfacción con el tratamiento (P >0.05). Las náuseas agudas y las arcadas, las náuseas, los vómitos y las arcadas tardías, la medida del índice de vida funcional y la satisfacción con el tratamiento mejoraron efectivamente en los grupos de acupresión y articulares (P < 0,05). Conclusión: El jengibre con acupresión P6 puede contribuir a mejorar las nviq en pacientes sometidos a quimioterapia.

RESUMO Objetivo: Avaliar os efeitos da compressão do acuponto gengibre e Neiguan na prevenção e tratamento de náuseas e vômitos induzidos por quimioterapia em pacientes oncológicos. Métodos: Um total de 172 pacientes hospitalizados no Hospital Afiliado da Xuzhou Medical University de fevereiro a setembro de 2022 foram divididos aleatoriamente em grupo controle, grupo gengibre, grupo acuponto e grupo combinado. A recolha de dados incluiu principalmente dados basais, pontuação de náuseas, vómitos e vómitos, sensação de benefício da doença, índice de vida funcional, satisfação com o tratamento e efeitos adversos. Resultados: Não houve diferenças significativas no benefício da doença e efeitos adversos entre os quatro grupos (P >0,05). O gengibre melhorou significativamente o índice de vida funcional tardia e náusea (P < 0,05), mas não melhorou a NVI tardia e vómitos e vómitos retardados, o índice de vida funcional dos vómitos e a satisfação com o tratamento (P >0,05). Ambos os grupos de acuponto e combinação melhoraram náuseas agudas, vómitos, náuseas tardias, vómitos, vómitos, vómitos, índice de vida funcional e satisfação com o tratamento (P < 0,05). Conclusão: A acupuntura de gengibre e neiguan pode ajudar a melhorar a NVIQ em pacientes submetidos a quimioterapia.

Infertility associated with Zinner syndrome: a case report / 中华泌尿外科杂志

Zinner syndrome is a congenital genitourinary embryo malformation, which is clinically rare, difficult to diagnose, and usually found in the sexually active stage. MRI is the preferred method for diagnosis. Conservative treatment was usually conducted for most asymptomatic patients. Symptomatic patients can be treated by laparoscopic or robotic surgery. For patients with infertility complicated with ejaculatory duct obstruction, transurethral resection of the ejaculatory duct is feasible, which contributes to improving sperm vitality and quantity and increasing semen volume. However, some patients still have azoospermia after surgery. The etiology is needed further studied. A case of infertility with Zinner syndrome and ectopic ureteral opening in seminal vesicle cyst is reported.

Discussions about Teaching Model of Mathematics for Chinese Medical University / 中华医学教育探索杂志

Aiming at the characteristics of Chinese medical university,the paper discusses the teaching model of mathematics,including the setup as well as content of curriculum,course examination and teaching method.Under the new teaching pattern,the students not only have a good command of mathematics but also develop the ability of knowledge application.

Contribution of basal and early phase insulin secretion to plasma glucose level in patients with type 2 diabetes / 中华内分泌代谢杂志

Objective To investigate the effects of basal and early phase insulin secretion on plasma glucose level in type 2 diabetes. Methods Plasma glucose and true insulin levels were measured at 0, 30, 60, 120 min during standard meal test in 81 patients with type 2 diabetes. Insulin sensitivity index (ISI) and insulin secretion index (?I 30 /?G 30 ) were calculated for evaluating the insulin sensitivity. Contributions of basal and early insulin secretion to plasma glucose level were evaluated by multivariate regression analysis with SAS software. Results ISI and ?I 30 /?G 30 showed nearly equal effects on plasma glucose levels by multivariate regression analysis. Among insulin levels of different time points during standard meal test, basal and postprandial 60 min insulin levels played important roles in changes of plasma glucose levels. The effect of fasting insulin on the area under plasma glucose curve was stronger than that of ?I 30 /?G 30 . Conclusion Both basal and early insulin secretions greatly contribute to glycemic control.

Insulin resistance and function of islet ? cell of the first-degree relatives of T2DM with normal glucose tolerance / 中国糖尿病杂志

To investigate the insulin resistance and insulin secretion of the first degree relatives of T2DM with normal glucose tolerance(NGT). The levels of FIns and HOMA-IR in the groups of the parental (n=35) and the maternal (n=58) were higher than that in the group of the paternal (n=42), bwt the IAI and △I_ 30 /△G_ 30 were lower than that in the group of paternal. This suggests the first-degree relatives of type 2 diabetes have insulin resistance and impaired first phase insulin secretion in NGT.

Relationship between metabolic syndrome and obesity in an urban population of Qingdao / 中华内分泌代谢杂志

The relation of metabolic syndrome and its components with body mass index (BMI) was investigated in Zhanshan community, Qingdao. The results showed that the prevalence and relative risk of metabolic syndrome and its components were increased with BMI. Nearly one-third of individuals with overweight or obesity had metabolic syndrome.