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Acta Academiae Medicinae Sinicae ; (6): 728-731, 2008.
Artículo en Chino | WPRIM | ID: wpr-259093

RESUMEN

<p><b>OBJECTIVE</b>To investigate the expressions of prostate stem cell antigen (PSCA) and Claudin-4 in human pancreatic carcinoma and to discuss its role in the ontogenesis of pancreatic cancer.</p><p><b>METHODS</b>Pancreatic carcinoma tissue microarray was constructed, containing 100 cores of 10 normal adult pancreas tissues, 12 chronic pancreatitis tissues, and 78 pancreatic carcinomas. The expressions of PSCA and Claudin-4 were detected using immunohistochemical method and the relationship between PSCA and Claudin-4 and the pancreatic carcinoma was analyzed.</p><p><b>RESULTS</b>The positive expression rates of PSCA and Claudin-4 protein in pancreatic carcinoma were 79. % and 88. % respectively. PSCA and Claudin-4 staining were more intense in malignant cells than in chronic pancreatic tissues and normal adult pancreas tissues. No evidence was found for an association between expressions of PSCA and Claudin-4 and other variables, including gender, age at surgery, and tumor grade.</p><p><b>CONCLUSIONS</b>The expressions of PSCA and Claudin-4 are related to the pancreatic carcinomas. PSCA and Claudin-4 play a role in the development of pancreatic cancer, but PSCA and Claudin-4 are not correlated with the clinical pathology of tumor.</p>


Asunto(s)
Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Antígenos de Neoplasias , Carcinoma , Genética , Metabolismo , Patología , Claudina-4 , Proteínas Ligadas a GPI , Regulación Neoplásica de la Expresión Génica , Glicoproteínas de Membrana , Genética , Metabolismo , Proteínas de la Membrana , Genética , Metabolismo , Proteínas de Neoplasias , Genética , Metabolismo , Neoplasias Pancreáticas , Genética , Metabolismo , Patología , Regulación hacia Arriba
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